Recombinant IL13RA1 Protein, Human (His & Fc Tag) Recombinant Proteins The human IL13Rα1 (NP_001551.1) extracellular domain (Met 1-Thr 343) was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus The recombinant human IL13Rα1/Fc is a disulfide-linked homodimer. The reduced monomer consists of 570a.a and has a predicted molecular weight of 65 kDa. As a result of glycosylation, the apparent molecular weight of rh IL13Rα1/Fc monomer migrates with an apparent molecular weight of 85-95 kDa in SDS
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Formulation: The recombinant human IL13Rα1/Fc is a disulfide-linked homodimer. The reduced monomer consists of 570a.a and has a predicted molecular weight of 65 kDa. As a result of glycosylation, the apparent molecular weight of rh IL13Rα1/Fc monomer migrates with an apparent molecular weight of 85-95 kDa in SDS
Source: HEK293 Cells
Usage: Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use

Recombinant IL13RA1 Protein, Human (His & Fc Tag)

Formulation: Recombinant IL13RA1 Protein was lyophilized from sterile PBS, pH 7.41

Source: HEK293 Cells

Product Name Recombinant IL13RA1 Protein, Human (His & Fc Tag)
Product Type Recombinant Protein
Source HEK293 Cells
Formulation Recombinant IL13RA1 Protein was lyophilized from sterile PBS, pH 7.41
Molecular Weight The recombinant human IL13Rα1/Fc is a disulfide-linked homodimer. The reduced monomer consists of 570a.a and has a predicted molecular weight of 65 kDa. As a result of glycosylation, the apparent molecular weight of rh IL13Rα1/Fc monomer migrates with an apparent molecular weight of 85-95 kDa in SDS
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method
Purity Greater than 97% as determined by SDS-PAGE
Description The human IL13Rα1 (NP_001551.1) extracellular domain (Met 1-Thr 343) was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus
Host Species Homo sapiens (Human)
Usage Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use
Storage Store recombinant protein under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
AA Sequence Met 1-Thr 343
Product Background Interleukin 13 receptor, alpha 1, also known as IL13RA1/IL-13RA1 and CD213A1 (cluster of differentiation 213A1), is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha, a subunit shared by IL13 and IL4 receptors. IL13RA1/IL-13RA1 serves as a primary IL13-binding subunit of the IL13 receptor, and may also be a component of IL4 receptors. This protein has been shown to bind tyrosine kinase TYK2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4. IL13RA1/IL-13RA1 binds with low affinity to interleukin-13 (IL13). This subunit together with IL4RA can form a functional receptor for IL13. IL13RA1/IL-13RA1 also serves as an alternate accessory protein to the common cytokine receptor gamma chain for interleukin-4 (IL4) signaling, but cannot replace the function of IL2RG in allowing enhanced interleukin-2 (IL2) binding activity.
Memo CD213A1 Protein, Human;IL-13Ra Protein, Human;NR4 Protein, Human
Terminal Gly 22
Bioactivity Measured by its binding ability in a functional ELISA. Immobilized cynomolgus IL-13 at 4 ug/ml (100 ul/well) can bind human IL13RA1-Fc with a linear ranger of 0.156-2.5 ug/ml.