Recombinant ICOS Protein, Rhesus (Fc Tag) Recombinant Proteins The rhesus ICOS (NP_001253918.1) (Met1-Lys140) was expressed with the Fc region of human IgG1 at the C-terminus The recombinant rhesus ICOS consists of 378a.a and predicts a molecular weight of 42.7 kDa.
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Formulation: The recombinant rhesus ICOS consists of 378a.a and predicts a molecular weight of 42.7 kDa.
Source: HEK293 Cells
Usage: Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use

Recombinant ICOS Protein, Rhesus (Fc Tag)

Formulation: Recombinant ICOS Protein was lyophilized from sterile PBS, pH 7.4.1

Source: HEK293 Cells

Product Name Recombinant ICOS Protein, Rhesus (Fc Tag)
Product Type Recombinant Protein
Source HEK293 Cells
Formulation Recombinant ICOS Protein was lyophilized from sterile PBS, pH 7.4.1
Molecular Weight The recombinant rhesus ICOS consists of 378a.a and predicts a molecular weight of 42.7 kDa.
Endotoxin < 1.0 EU per μg protein as determined by the LAL method
Purity Greater than 90% as determined by SDS-PAGE.
Description The rhesus ICOS (NP_001253918.1) (Met1-Lys140) was expressed with the Fc region of human IgG1 at the C-terminus
Host Species Rhesus
Usage Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use
Storage Store recombinant protein under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
AA Sequence Met1-Lys140
Product Background Inducible costimulator (ICOS), also called AILIM (activiation-inducible lymphocyte immunomediatory molecule) is a cell-surface receptor, and belongs to the CD28 family of immune costimulatory receptors consisting of CD28, CTLA-4 and PD-1. The interaction of B7-H2/ICOS plays a critical role in Th cell differentiation, T−B cell interactions which is essential for germinal center formation, and humoral immune responses, and as well as the production of cytokine IL-4. In addition, ICOS is more potent in the induction of IL-1 production, a cytokine important for suppressive function of T regulatory cells. The B7-1/B7-2--CD28/CTLA-4 and ICOS-B7RP-1 pathway provides key second signals that can regulate the activation, inhibition and fine-tuning of T-lymphocyte responses. ICOS stimulates both Th1 and Th2 cytokine production but may have a preferential role in Th2 cell development. Moreover, The B7-1/B7-2-CD28/CTLA-4 and ICOS-B7RP-1 pathway has been suggested of being involved in the development of airway inflammation and airway hyperresponsiveness.Immune CheckpointImmune Checkpoint ProteinsImmune Checkpoint TargetsCo-stimulatory Immune Checkpoint Targets ImmunotherapyCancer ImmunotherapyTargeted Therapy
Terminal Met
Bioactivity Please contact us for detailed information