Recombinant IDO Protein, Human Recombinant Proteins The human IDO1 (NP_002155.1) (Ala2-Gly403) was expressed and purified with one additional amino acids (Gly) at the N-terminus The recombinant human IDO1 consists of 403a.a and predicts a molecular weight of 45.2 KDa. It migrates as an approximately 46 KDa band in SDS-PAGE under reducing conditions.
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Formulation: The recombinant human IDO1 consists of 403a.a and predicts a molecular weight of 45.2 KDa. It migrates as an approximately 46 KDa band in SDS-PAGE under reducing conditions.
Source: E. coli
Usage: Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use

Recombinant IDO Protein, Human

The product is for non-human research only. Not for therapeutic or veterinary use.

Catalog No: bt-202384

Molecular Weight: The recombinant human IDO1 consists of 403a.a and predicts a molecular weight of 45.2 KDa. It migrates as an approximately 46 KDa band in SDS-PAGE under reducing conditions.

Formulation: Recombinant IDO ProteinSupplied as sterile 50 mM NaAC, 100 mM Nacl, 20 % glycerol, pH 5.5.1

Source: E. coli

Product Name Recombinant IDO Protein, Human
Molecular Weight The recombinant human IDO1 consists of 403a.a and predicts a molecular weight of 45.2 KDa. It migrates as an approximately 46 KDa band in SDS-PAGE under reducing conditions.
AA Sequence Ala2-Gly403
Bioactivity Measured by its ability to oxidize L-tryptophan to N-formylk-ynurenine.The specific activity is > 500 pmoles/min/ug.
Formulation Recombinant IDO ProteinSupplied as sterile 50 mM NaAC, 100 mM Nacl, 20 % glycerol, pH 5.5.1
Host Species Homo sapiens (Human)
Description The human IDO1 (NP_002155.1) (Ala2-Gly403) was expressed and purified with one additional amino acids (Gly) at the N-terminus
Product Background Indoleamine 2,3-dioxygenase-1, also known as Indoleamine-pyrrole 2,3-dioxygenase, IDO1 and IDO, is a member of the indoleamine 2,3-dioxygenase family. IDO1 / IDO and tryptophan 2,3-dioxygenase (TDO) are tryptophan-degrading enzymes that catalyze the first step in tryptophan catabolism via the kynurenine pathway. TDO is widely distributed in both eukaryotes and bacteria. In contrast, IDO has been found only in mammals and yeast. In 27, a third enzyme, indoleamine 2,3-dioxygenase-2 (IDO2), was discovered. IDO2 is found not only in mammals but also in lower vertebrates. IDO1 / IDO is an immunosuppressive molecule inducible in various cells. IDO1 / IDO catalyzes the cleavage of the pyrrol ring of tryptophan and incorporates both atoms of a molecule of oxygen. It mediates oxidative cleavage of tryptophan, an amino acid essential for cell proliferation and survival. IDO1 / IDO inhibition is proposed to have therapeutic potential in immunodeficiency-associated abnormalities, including cancer. The IDO pathway is activated in multiple tumor types. Selective inhibition of IDO1 may represent an attractive cancer therapeutic strategy via up-regulation of cellular immunity. IDO1 / IDO is an enzyme that suppresses adaptive T-cell immunity by catabolizing tryptophan from the cellular microenvironment. Inhibition of IDO pathway might enhance the efficacy of immunotherapeutic strategies for cancer.Immune CheckpointImmune Checkpoint Detection: ELISA AntibodiesCo-inhibitory Immune Checkpoint Targets ImmunotherapyCancer ImmunotherapyTargeted Therapy
Product Memo IDO Protein, Human;IDO-1 Protein, Human;INDO Protein, Human;Indoleamine 2,3‑dioxygenase Protein, Human
Product Type Recombinant Protein
Purity Greater than 85% as determined by SDS-PAGE
Source E. coli
Storage Store recombinant protein under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Terminal Gly
Usage Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use
Last Modified Mar 08 2019