Recombinant IFNA4 Protein, Cynomolgus (Fc Tag) Recombinant Proteins The cynomolgus IFNA4 (Met1-Asn189) was expressed with Fc region of mouse IgG at the C-terminus The recombinant cynomolgus IFNA4 is a disulfide-linked homodimer. The reduced monomer comprises 400a.a and has a calculated molecular weight of 45.6 KDa.The apparent molecular weight of the protein is approximately 48 KDa respectively in SDS-PAGE.
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Formulation: The recombinant cynomolgus IFNA4 is a disulfide-linked homodimer. The reduced monomer comprises 400a.a and has a calculated molecular weight of 45.6 KDa.The apparent molecular weight of the protein is approximately 48 KDa respectively in SDS-PAGE.
Source: HEK293 Cells
Usage: Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use

Recombinant IFNA4 Protein, Cynomolgus (Fc Tag)

Formulation: Recombinant IFNA4 Protein was lyophilized from sterile PBS, pH 7.41

Source: HEK293 Cells

Product Name Recombinant IFNA4 Protein, Cynomolgus (Fc Tag)
Product Type Recombinant Protein
Source HEK293 Cells
Formulation Recombinant IFNA4 Protein was lyophilized from sterile PBS, pH 7.41
Molecular Weight The recombinant cynomolgus IFNA4 is a disulfide-linked homodimer. The reduced monomer comprises 400a.a and has a calculated molecular weight of 45.6 KDa.The apparent molecular weight of the protein is approximately 48 KDa respectively in SDS-PAGE.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method
Purity Greater than 90% as determined by SDS-PAGE
Description The cynomolgus IFNA4 (Met1-Asn189) was expressed with Fc region of mouse IgG at the C-terminus
Host Species Cynomolgus
Usage Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use
Storage Store recombinant protein under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
AA Sequence Met1-Asn189
Product Background Interferon, alpha 4 (IFNA4) belongs to the alpha/beta interferon family. Two variants of IFNA4 (IFNA4a and IFNA4b) are known, which differ from each other by changes in their coding regions at nucleotide positions 22 and 41 and can be distinguished by selective restriction enzyme analysis. Interferons are produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. IFN-alpha, the first cytokine to be produced by recombinant DNA technology, has emerged as an important regulator of growth and differentiation, affecting cellular communication and signal transduction pathways as well as immunological control. Originally discovered as an antiviral substance, the efficacy of IFN-alpha in malignant, viral, immunological, angiogenic, inflammatory, and fibrotic diseases suggests a spectrum of interrelated pathophysiologies. IFN-alpha emerged as a prototypic tumor suppressor protein that represses the clinical tumorigenic phenotype in some malignancies capable of differentiation.
Memo IFNA4 Protein, Cynomolgus
Terminal Cys 24
Bioactivity Measured in antiviral assay using WISH human amnion cells infected with vesicular stomatitisvirus (VSV).The ED50 for this effect is 0.03-0.3 ng/mL.