Recombinant IFNA4 Protein, Human (Fc Tag) Recombinant Proteins The mature form of human IFN-α4a (NP_066546.1) (Cys 23-Asp 189) was expressed with the N-terminal fused Fc region of human IgG1 The recombinant human Fc/IFN-α4a is a disulfide-linked homodimeric protein. The reduced monomer consists of 403a.a and has a predicted molecular weight of 46 kDa. As a result of glycosylation, the apparent molecular weight of rh Fc/IFN-α4a monomer is approximately 50 kDa in SDS-PAGE under reducing c
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Formulation: The recombinant human Fc/IFN-α4a is a disulfide-linked homodimeric protein. The reduced monomer consists of 403a.a and has a predicted molecular weight of 46 kDa. As a result of glycosylation, the apparent molecular weight of rh Fc/IFN-α4a monomer is approximately 50 kDa in SDS-PAGE under reducing c
Source: HEK293 Cells
Usage: Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use

Recombinant IFNA4 Protein, Human (Fc Tag)

Formulation: Recombinant IFNA4 Protein was lyophilized from sterile PBS, pH 7.41

Source: HEK293 Cells

Product Name Recombinant IFNA4 Protein, Human (Fc Tag)
Product Type Recombinant Protein
Source HEK293 Cells
Formulation Recombinant IFNA4 Protein was lyophilized from sterile PBS, pH 7.41
Molecular Weight The recombinant human Fc/IFN-α4a is a disulfide-linked homodimeric protein. The reduced monomer consists of 403a.a and has a predicted molecular weight of 46 kDa. As a result of glycosylation, the apparent molecular weight of rh Fc/IFN-α4a monomer is approximately 50 kDa in SDS-PAGE under reducing c
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method
Purity Greater than 97% as determined by SDS-PAGE
Description The mature form of human IFN-α4a (NP_066546.1) (Cys 23-Asp 189) was expressed with the N-terminal fused Fc region of human IgG1
Host Species Homo sapiens (Human)
Usage Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use
Storage Store recombinant protein under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
AA Sequence Cys 23-Asp 189
Product Background Interferon, alpha 4 (IFNA4) belongs to the alpha/beta interferon family. Two variants of IFNA4 (IFNA4a and IFNA4b) are known, which differ from each other by changes in their coding regions at nucleotide positions 22 and 41 and can be distinguished by selective restriction enzyme analysis. Interferons are produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. IFN-alpha, the first cytokine to be produced by recombinant DNA technology, has emerged as an important regulator of growth and differentiation, affecting cellular communication and signal transduction pathways as well as immunological control. Originally discovered as an antiviral substance, the efficacy of IFN-alpha in malignant, viral, immunological, angiogenic, inflammatory, and fibrotic diseases suggests a spectrum of interrelated pathophysiologies. IFN-alpha emerged as a prototypic tumor suppressor protein that represses the clinical tumorigenic phenotype in some malignancies capable of differentiation.
Memo IFN-alpha4a Protein, Human;INFA4 Protein, Human;MGC142200 Protein, Human
Terminal Glu
Bioactivity Measured in antiviral assays using WISH human amnion cells infected with vesicular stomatitis virus (VSV).The EC50 for this effect is 0.2-1 ng/mL.