Recombinant IFNA4 Protein, Human (His Tag) Recombinant Proteins The human IFNα 4a (NP_066546.1)) (Met 1-Asp 189) was fused with a polyhistidine tag at the C-terminus The recombinant human IFNα4a consists of 176a.a and predicts a molecular weight of 20.7 kDa. It migrates as an approximately 20 kDa band in SDS-PAGE under reducing conditions.
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Formulation: The recombinant human IFNα4a consists of 176a.a and predicts a molecular weight of 20.7 kDa. It migrates as an approximately 20 kDa band in SDS-PAGE under reducing conditions.
Source: Baculovirus-Insect Cells
Usage: Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use

Recombinant IFNA4 Protein, Human (His Tag)

Formulation: Recombinant IFNA4 Protein was lyophilized from sterile 20mM Tris, 500mM NaCl, pH 7.4, 10% gly1

Source: Baculovirus-Insect Cells

Product Name Recombinant IFNA4 Protein, Human (His Tag)
Product Type Recombinant Protein
Source Baculovirus-Insect Cells
Formulation Recombinant IFNA4 Protein was lyophilized from sterile 20mM Tris, 500mM NaCl, pH 7.4, 10% gly1
Molecular Weight The recombinant human IFNα4a consists of 176a.a and predicts a molecular weight of 20.7 kDa. It migrates as an approximately 20 kDa band in SDS-PAGE under reducing conditions.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method
Purity Greater than 88% as determined by SDS-PAGE
Description The human IFNα 4a (NP_066546.1)) (Met 1-Asp 189) was fused with a polyhistidine tag at the C-terminus
Host Species Homo sapiens (Human)
Usage Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use
Storage Store recombinant protein under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
AA Sequence Met 1-Asp 189
Product Background Interferon, alpha 4 (IFNA4) belongs to the alpha/beta interferon family. Two variants of IFNA4 (IFNA4a and IFNA4b) are known, which differ from each other by changes in their coding regions at nucleotide positions 22 and 41 and can be distinguished by selective restriction enzyme analysis. Interferons are produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. IFN-alpha, the first cytokine to be produced by recombinant DNA technology, has emerged as an important regulator of growth and differentiation, affecting cellular communication and signal transduction pathways as well as immunological control. Originally discovered as an antiviral substance, the efficacy of IFN-alpha in malignant, viral, immunological, angiogenic, inflammatory, and fibrotic diseases suggests a spectrum of interrelated pathophysiologies. IFN-alpha emerged as a prototypic tumor suppressor protein that represses the clinical tumorigenic phenotype in some malignancies capable of differentiation.
Memo IFN-alpha4a Protein, Human;INFA4 Protein, Human;MGC142200 Protein, Human
Terminal Cys 24
Bioactivity Measured in antiviral assays using WISH human amnion cells infected with vesicular stomatitis virus(VSV).The ED50 for this effect is typically 2-8 pg/mL.