Recombinant HGF Protein, Cynomolgus Recombinant Proteins The cynomolgus HGF (C9E9X5) (Met1-Ser728) was expressed The recombinant Cynomolgus HGF consists of 697a.a and has a calculated molecular weight of 79.6 KDa. It migrates as 89,58,34 and 32 KDa band in SDS-PAGE under reducing conditions.
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Formulation: The recombinant Cynomolgus HGF consists of 697a.a and has a calculated molecular weight of 79.6 KDa. It migrates as 89,58,34 and 32 KDa band in SDS-PAGE under reducing conditions.
Source: HEK293 Cells
Usage: Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use

Recombinant HGF Protein, Cynomolgus

Formulation: Recombinant HGF Protein was lyophilized from sterile PBS, pH 7.4.1

Source: HEK293 Cells

Product Name Recombinant HGF Protein, Cynomolgus
Product Type Recombinant Protein
Source HEK293 Cells
Formulation Recombinant HGF Protein was lyophilized from sterile PBS, pH 7.4.1
Molecular Weight The recombinant Cynomolgus HGF consists of 697a.a and has a calculated molecular weight of 79.6 KDa. It migrates as 89,58,34 and 32 KDa band in SDS-PAGE under reducing conditions.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method
Purity (49.5+35.5+6.4+7.1)% as determined by SDS-PAGE
Description The cynomolgus HGF (C9E9X5) (Met1-Ser728) was expressed
Host Species Cynomolgus
Usage Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use
Storage Store recombinant protein under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
AA Sequence Met1-Ser728
Product Background Hepatocyte growth factor, also known as HGF, contains 4 kringle domains, 1 PAN domain and 1 peptidase S1 domain. It belongs to the peptidase S1 family, plasminogen subfamily. Hepatocyte growth factor is secreted by mesenchymal cellsas a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor, and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. HGF is a potent mitogen for mature parenchymal hepatocyte cells, seems to be an hepatotrophic factor, and acts as growth factor for a broad spectrum of tissues and cell types. HGF has no detectable protease activity. Defects in hepatocyte growth factor are the cause of deafness autosomal recessive type 39. A form of profound prelingual sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.Immune CheckpointImmunotherapyCancer ImmunotherapyTargeted Therapy
Uniprot Number C9E9X5
Terminal His 32
Bioactivity 1. Immobilized Cynomolgus HGF at 10 ug/ml (100 ul/well) can bind Cynomolgus MET-Fc, EC50 of Cynomolgus MET-Fc is 0.04-0.09 ug/ml.2. Measured by its ability to inhibit TGFß1 activity on Mv-1-lu mink lung epithelial cells. The ED50 for this effect is typically 2-10 ng/ml.