Recombinant HGF Protein, Human Recombinant Proteins The human HGF (NP_000592.3) precursor (Met 1-Ser 728) was expressed and purified The secreted recombinant human HGF consists of 697a.a after cleavage of the signal peptide and has a predicted molecular weight of 79.7 kDa. The HGF single chain can be processed into the active form of disulfide-linked heterodimer of α and β chain. As a result of glycosylation, it migrates with the
$ $99 In stock
Formulation: The secreted recombinant human HGF consists of 697a.a after cleavage of the signal peptide and has a predicted molecular weight of 79.7 kDa. The HGF single chain can be processed into the active form of disulfide-linked heterodimer of α and β chain. As a result of glycosylation, it migrates with the
Source: CHO Stable Cells
Usage: Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use

Recombinant HGF Protein, Human

Formulation: Recombinant HGF Protein was lyophilized from sterile PBS, pH 7.41

Source: CHO Stable Cells

Product Name Recombinant HGF Protein, Human
Product Type Recombinant Protein
Source CHO Stable Cells
Formulation Recombinant HGF Protein was lyophilized from sterile PBS, pH 7.41
Molecular Weight The secreted recombinant human HGF consists of 697a.a after cleavage of the signal peptide and has a predicted molecular weight of 79.7 kDa. The HGF single chain can be processed into the active form of disulfide-linked heterodimer of α and β chain. As a result of glycosylation, it migrates with the
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method
Purity Greater than 93% as determined by SDS-PAGE
Description The human HGF (NP_000592.3) precursor (Met 1-Ser 728) was expressed and purified
Host Species Homo sapiens (Human)
Usage Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use
Storage Store recombinant protein under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
AA Sequence Met 1-Ser 728
Product Background Hepatocyte growth factor, also known as HGF, contains 4 kringle domains, 1 PAN domain and 1 peptidase S1 domain. It belongs to the peptidase S1 family, plasminogen subfamily. Hepatocyte growth factor is secreted by mesenchymal cellsas a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor, and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. HGF is a potent mitogen for mature parenchymal hepatocyte cells, seems to be an hepatotrophic factor, and acts as growth factor for a broad spectrum of tissues and cell types. HGF has no detectable protease activity. Defects in hepatocyte growth factor are the cause of deafness autosomal recessive type 39. A form of profound prelingual sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.Immune CheckpointImmunotherapyCancer ImmunotherapyTargeted Therapy
Memo DFNB39 Protein, Human;F-TCF Protein, Human;F-TCFB Protein, Human;Hepatocyte Growth Factor Protein, Human;HGFB Protein, Human;HPTA Protein, Human;SF Protein, Human
Terminal Gln 32 (α chain) & Val 495 (β chain)
Bioactivity Measured by its ability to neutralize TGF-beta mediated inhibition on Mv-1-Lu cell proliferation.The ED50 for this effect is typically 2-10 ng/mL.