Recombinant gp130 Protein, Rat (His Tag) Recombinant Proteins The rat IL6ST (NP_001008725.2) extracellular domain (Met 4-Glu 618) was fused with a polyhistidine tag at the C-terminus The secreted recombinant rat IL6ST comprises 607a.a and predicts a molecular weight of 68.2 kDa. The apparent molecular weight of the rat IL6ST is approximately 90-100 kDa in SDS-PAGE under reducing conditions due to glycosylation.
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Formulation: The secreted recombinant rat IL6ST comprises 607a.a and predicts a molecular weight of 68.2 kDa. The apparent molecular weight of the rat IL6ST is approximately 90-100 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Source: HEK293 Cells
Usage: Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use

Recombinant gp130 Protein, Rat (His Tag)

Formulation: Recombinant gp130 Protein was lyophilized from sterile PBS, pH 7.41

Source: HEK293 Cells

Product Name Recombinant gp130 Protein, Rat (His Tag)
Product Type Recombinant Protein
Source HEK293 Cells
Formulation Recombinant gp130 Protein was lyophilized from sterile PBS, pH 7.41
Molecular Weight The secreted recombinant rat IL6ST comprises 607a.a and predicts a molecular weight of 68.2 kDa. The apparent molecular weight of the rat IL6ST is approximately 90-100 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method
Purity Greater than 97% as determined by SDS-PAGE
Description The rat IL6ST (NP_001008725.2) extracellular domain (Met 4-Glu 618) was fused with a polyhistidine tag at the C-terminus
Host Species Rat
Usage Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use
Storage Store recombinant protein under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
AA Sequence Met 4-Glu 618
Product Background Glycoprotein 13 (also known as gp13, IL6ST, IL6-beta or CD13) is a transmembrane protein which is the founding member of the class of all cytokine receptors. CD13/gp13 is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and Oncostatin M (OSM). CD13/gp13 functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. CD13/gp13 plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. A related pseudogene has been identified on chromosome 17. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp13 for initiating signal transmission. CD13/gp13 binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. CD13/gp13 may have a role in embryonic development. The type I OSM receptor is capable of transducing OSM-specific signaling events.
Terminal Gln 23
Bioactivity Measured by its ability to inhibit the IL6 Rα enhancement of IL6 activity on M1 mouse myeloid leukemia cells (Saito, T. et al. 1991, J. Immunol. 147 168.). The ED50 for this effect is typically 0.5-2 ug/ml in the presence of 50 ng/ml recombinant human IL6sR and 100 ng/ml recombinant human IL6.