Recombinant FLT1 Protein, Human (His Tag) Recombinant Proteins The human FLT1 (NP_002010.2) (Met1-Ile328) was expressed with a polyhistidine tag at the C-terminus The recombinant human FLT1 consists 313a.a and predicts a molecular weight of 35.6 kDa.
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Formulation: The recombinant human FLT1 consists 313a.a and predicts a molecular weight of 35.6 kDa.
Source: HEK293 Cells
Usage: Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use

Recombinant FLT1 Protein, Human (His Tag)

Formulation: Recombinant FLT1 Protein was lyophilized from sterile PBS, pH 7.4.1

Source: HEK293 Cells

Product Name Recombinant FLT1 Protein, Human (His Tag)
Product Type Recombinant Protein
Source HEK293 Cells
Formulation Recombinant FLT1 Protein was lyophilized from sterile PBS, pH 7.4.1
Molecular Weight The recombinant human FLT1 consists 313a.a and predicts a molecular weight of 35.6 kDa.
Endotoxin < 1.0 EU per μg protein as determined by the LAL method
Purity Greater than 90% as determined by SDS-PAGE.
Description The human FLT1 (NP_002010.2) (Met1-Ile328) was expressed with a polyhistidine tag at the C-terminus
Host Species Homo sapiens (Human)
Usage Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use
Storage Store recombinant protein under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
AA Sequence Met1-Ile328
Product Background Vascular endothelial growth factor receptor 1, also known as VEGFR-1, Fms-like tyrosine kinase 1, Tyrosine-protein kinase FRT, Tyrosine-protein kinase receptor FLT, Vascular permeability factor receptor and FLT1, is a single-pass type I membrane protein and secreted protein which belongs to theprotein kinase superfamily, Tyr protein kinase family and CSF-1/PDGF receptor subfamily. VEGFR-1 / FLT1 contains sevenIg-like C2-type (immunoglobulin-like) domains and oneprotein kinase domain. VEGFR-1 / FLT1 is expressed mostly in normal lung, but also in placenta, liver, kidney, heart and brain tissues. It is specifically expressed in most of the vascular endothelial cells, and also expressed in peripheral blood monocytes. VEGFR-1 / FLT1 is not expressed in tumor cell lines. VEGFR-1 / FLT1 is an essential receptor tyrosine kinase that regulates mammalian vascular development and embryogenesis. EGF-induced angiogenesis requires inverse regulation of VEGFR-1 and VEGFR-2 in tumor-associated endothelial cells. VEGFR-1 / FLT1 is a receptor for VEGF, VEGFB and PGF. It has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability.Immune CheckpointImmunotherapyCancer ImmunotherapyTargeted Therapy
Memo FLT Protein, Human;FLT-1 Protein, Human;VEGFR-1 Protein, Human;VEGFR1 Protein, Human
Terminal Ser 27
Bioactivity Measured by its ability to inhibit the VEGF-dependent proliferation of human umbilical vein endothelial cells ( HUVEC ). ( Conn, G. et al. ,1990 , Proc. Natl. Acad. Sci. USA 87 1323. )The ED50 for this effect is typically 10-40 ng/mL in the presence of 10 ng/mL human VEGF165.