Recombinant FLT4 Protein, Mouse (Fc Tag) Recombinant Proteins The mouse FLT4 (P35917-1) extracellular domain (Met 1-Glu 775) was was fused with the Fc region of human IgG1 at the C-terminus The secreted recombinant mouse FLT4/Fc chimera is a disulfide-linked homodimer. The reduced monomer consists of 992a.a and has a predicted molecular weight of 112 kDa. As a result of glycosylation and proteolytic cleavage, rm FLT4/Fc monomer migrates as three bands (150, 85, 65 kDa) corresponding to
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Formulation: The secreted recombinant mouse FLT4/Fc chimera is a disulfide-linked homodimer. The reduced monomer consists of 992a.a and has a predicted molecular weight of 112 kDa. As a result of glycosylation and proteolytic cleavage, rm FLT4/Fc monomer migrates as three bands (150, 85, 65 kDa) corresponding to
Source: HEK293 Cells
Usage: Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use

Recombinant FLT4 Protein, Mouse (Fc Tag)

Formulation: Recombinant FLT4 Protein was lyophilized from sterile PBS, pH 7.41

Source: HEK293 Cells

Product Name Recombinant FLT4 Protein, Mouse (Fc Tag)
Product Type Recombinant Protein
Source HEK293 Cells
Formulation Recombinant FLT4 Protein was lyophilized from sterile PBS, pH 7.41
Molecular Weight The secreted recombinant mouse FLT4/Fc chimera is a disulfide-linked homodimer. The reduced monomer consists of 992a.a and has a predicted molecular weight of 112 kDa. As a result of glycosylation and proteolytic cleavage, rm FLT4/Fc monomer migrates as three bands (150, 85, 65 kDa) corresponding to
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method
Purity Greater than 92% as determined by SDS-PAGE
Description The mouse FLT4 (P35917-1) extracellular domain (Met 1-Glu 775) was was fused with the Fc region of human IgG1 at the C-terminus
Host Species Mouse
Usage Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use
Storage Store recombinant protein under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
AA Sequence Met 1-Glu 775
Product Background Vascular endothelial growth factor receptor 3 (VEGFR3), also known as FLT-4, together with the other two members VEGFR1 (FLT-1) and VEGFR2 (KDR/Flk-1) are receptors for vascular endothelial growth factors (VEGF) and belong to the class III subfamily of receptor tyrosine kinases (RTKs). The VEGFR3 protein is expressed mainly on lymphatic vessels but it is also up-regulated in tumor angiogenesis. Mutations in VEGFR3 have been identified in patients with primary lymphoedema. The VEGF-C/VEGF-D/VEGFR3 signaling pathway may provide a target for antilymphangiogenic therapy in prostate cancer, breast cancer, gastric cancer, lung cancer, non-small cell lung cancer (NSCLC), and so on.Immune CheckpointImmunotherapyCancer ImmunotherapyTargeted Therapy
Memo AI323512 Protein, Mouse;Chy Protein, Mouse;Flt-4 Protein, Mouse;VEGFR-3 Protein, Mouse;VEGFR3 Protein, Mouse
Uniprot Number P35917
Terminal Tyr 25
Bioactivity 1. Measured by its ability to bind human VEGF-D in functional ELISA.2. Immobilized human VEGF-C at 10 ug/mL (100 uL/well) can bind mouse VEGFR3-Fc.The EC50 of mouse VEGFR3-Fc is 0.008 ug/mL.3. Measured by its ability to bind with mouse FIGF-His in a functional ELISA.