Recombinant FKBP12 Protein, Human (His Tag) Recombinant Proteins The human FKBP12 (NP_463460) (Met 1-Glu 108) was expressed with a C-terminal polyhistidine tag The recombinant human FKBP12 consists of 114a.a and predicts a molecular weight of 12.9 kDa as estimated by SDS-PAGE.
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Formulation: The recombinant human FKBP12 consists of 114a.a and predicts a molecular weight of 12.9 kDa as estimated by SDS-PAGE.
Source: E. coli
Usage: Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use

Recombinant FKBP12 Protein, Human (His Tag)

Formulation: Recombinant FKBP12 Protein was lyophilized from sterile PBS, 10% glycerol, pH 7.41

Source: E. coli

Product Name Recombinant FKBP12 Protein, Human (His Tag)
Product Type Recombinant Protein
Source E. coli
Formulation Recombinant FKBP12 Protein was lyophilized from sterile PBS, 10% glycerol, pH 7.41
Molecular Weight The recombinant human FKBP12 consists of 114a.a and predicts a molecular weight of 12.9 kDa as estimated by SDS-PAGE.
Purity Greater than 96% as determined by SDS-PAGE
Description The human FKBP12 (NP_463460) (Met 1-Glu 108) was expressed with a C-terminal polyhistidine tag
Host Species Homo sapiens (Human)
Usage Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use
Storage Store recombinant protein under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
AA Sequence Met 1-Glu 108
Product Background FK56 binding protein 12 (FKBP12), also known as FKBP1, along with cyclophilin, are two major members of the immunophilin protein family who serve as receptors for the immunosuppressant drugs cyclosporin A and FK56. As a conserved molecules in many eukaryotes, FKBP12 has been characterized as a peptidyl-prolyl isomerase that catalyzes the transition between cis- and trans-proline residues, and is involved in several biochemical processes including protein folding, receptor signaling, protein trafficking and transcription. FKBP12 has attracted immense attention and its role in mediating the immunosuppressive functions. FKBP12 serves a dual role as a peptidyl-prolyl cis-trans isomerase and as a modulator of several cell signaling pathways. In one such a role, FKBP12 interacts with and regulates the functional state of the ryanodine Ca2+ channel receptor by altering protein conformation and coordinating multi-protein complex formation. Another physiological role of FKBP12 is an interactor and a regulator of the type I serine/threonine kinase receptors of TGF-beta superfamily. Current data, derived from detailed biochemical studies as well as from functional studies in various systems, suggest that FKBP12 functions as a "guardian" for the type I receptors to prevent them from leaky signaling under sub-optimal ligand concentrations, thereby providing a molecular "gradient reader" for TGF-beta family morphogens. This aspect of FKBP12 function may be critical for cellular responsiveness to morphogenetic gradients of the TGF-beta family members during early development, serving to assure the translation of different ligand concentrations into different signaling readouts. In addition, FKBP12 may be involved in neuronal or astrocytic cytoskeletal organization and in the abnormal metabolism of tau protein in Alzheimer's disease (AD) damaged neurons.
Memo FKBP-12 Protein, Human;FKBP-1A Protein, Human;FKBP1 Protein, Human;FKBP12 Protein, Human;PKC12 Protein, Human;PKCI2 Protein, Human;PPIASE Protein, Human
Terminal Met 1
Bioactivity Please contact us for detailed information