Recombinant FGFR2 Protein, Human (ECD, His Tag) Recombinant Proteins The human FGFR2-alpha(IIIb) (NP_075259.4) (Met1-Glu378) was expressed with a polyhistidine tag at the C-terminus The recombinant human FGFR2-alpha(IIIb) consists 368a.a and predicts a molecular weight of 41.1 kDa.
$ $99 In stock
Formulation: The recombinant human FGFR2-alpha(IIIb) consists 368a.a and predicts a molecular weight of 41.1 kDa.
Source: HEK293 Cells
Usage: Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use

Recombinant FGFR2 Protein, Human (ECD, His Tag)

Formulation: Recombinant FGFR2 Protein was lyophilized from sterile PBS, pH 7.4.1

Source: HEK293 Cells

Product Name Recombinant FGFR2 Protein, Human (ECD, His Tag)
Product Type Recombinant Protein
Source HEK293 Cells
Formulation Recombinant FGFR2 Protein was lyophilized from sterile PBS, pH 7.4.1
Molecular Weight The recombinant human FGFR2-alpha(IIIb) consists 368a.a and predicts a molecular weight of 41.1 kDa.
Endotoxin < 1.0 EU per μg protein as determined by the LAL method
Purity Greater than 95% as determined by SDS-PAGE.
Description The human FGFR2-alpha(IIIb) (NP_075259.4) (Met1-Glu378) was expressed with a polyhistidine tag at the C-terminus
Host Species Homo sapiens (Human)
Usage Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use
Storage Store recombinant protein under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
AA Sequence Met1-Glu378
Product Background FGFR2, also known as CD332, belongs to the fibroblast growth factor receptor subfamily where amino acid sequence is highly conserved between members and throughout evolution. FGFR2 acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. It is required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. FGFR2 plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. It also promotes cell proliferation in keratinocytes and imature osteoblasts, but promotes apoptosis in differentiated osteoblasts. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal CD332 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1. Defects in CD3322 are the cause of Crouzon syndrome, Jackson-Weiss syndrome, Apert syndrome, Pfeiffer syndrome, Beare-Stevenson cutis gyrata syndrome, familial scaphocephaly syndrome, lacrimo-auriculo-dento-digital syndrome and Antley-Bixler syndrome without genital anomalies or disordered steroidogenesis.Immune CheckpointImmunotherapyCancer ImmunotherapyTargeted Therapy
Memo BBDS Protein, Human;BEK Protein, Human;BFR-1 Protein, Human;CD332 Protein, Human;CEK3 Protein, Human;CFD1 Protein, Human;ECT1 Protein, Human;JWS Protein, Human;K-SAM Protein, Human;KGFR Protein, Human;TK14 Protein, Human;TK25 Protein, Human
Terminal Arg 22
Bioactivity Please contact us for detailed information