Recombinant EGFL7 Protein, Human (His Tag) Recombinant Proteins The mature form of human EGFL7 (NP_057299.1) (Tyr 24-Ser 273) was expressed, with a polyhistidine tag at the N-terminus The recombinant human EGFL7 consists of 268a.a and predicts a molecular weight of 29.4 kDa. It migrates as an approximately 31 kDa band in SDS-PAGE under reducing conditions.
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Formulation: The recombinant human EGFL7 consists of 268a.a and predicts a molecular weight of 29.4 kDa. It migrates as an approximately 31 kDa band in SDS-PAGE under reducing conditions.
Source: Baculovirus-Insect Cells
Usage: Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use

Recombinant EGFL7 Protein, Human (His Tag)

The product is for non-human research only. Not for therapeutic or veterinary use.

Catalog No: bt-203164

Molecular Weight: The recombinant human EGFL7 consists of 268a.a and predicts a molecular weight of 29.4 kDa. It migrates as an approximately 31 kDa band in SDS-PAGE under reducing conditions.

Formulation: Recombinant EGFL7 Protein was lyophilized from sterile 100mM Glycine, 10mM NaCl, 10% glycerol, pH 7.01

Source: Baculovirus-Insect Cells

Product Name Recombinant EGFL7 Protein, Human (His Tag)
Molecular Weight The recombinant human EGFL7 consists of 268a.a and predicts a molecular weight of 29.4 kDa. It migrates as an approximately 31 kDa band in SDS-PAGE under reducing conditions.
AA Sequence Tyr 24-Ser 273
Bioactivity 1. Measured by the ability of the immobilized protein to support the adhesion of Jurkat cells. When 5 x 10E4 cells/well are added to Recombinant Human EGFL7 coated plates (5 ug/mL with 100 uL/well), >70% cells will adhere after 1 hour incubation at 37℃.2. Measured by its ability to bind human NOTCH1 in a functional ELISA.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method
Formulation Recombinant EGFL7 Protein was lyophilized from sterile 100mM Glycine, 10mM NaCl, 10% glycerol, pH 7.01
Host Species Homo sapiens (Human)
Description The mature form of human EGFL7 (NP_057299.1) (Tyr 24-Ser 273) was expressed, with a polyhistidine tag at the N-terminus
Product Background Epidermal growth factor-like protein 7, also known as EGF-like protein 7, Multiple epidermal growth factor-like domains protein 7, Multiple EGF-like domains protein 7, Vascular endothelial statin, NOTCH4-like protein and EGFL7, is a secreted protein which contains twoEGF-like domains and oneEMI domain. EGFL7 was identified by a number of groups as a putative secreted factor produced by the vascular endothelial cells (ECs). EGFL7 is described as a novel endothelial cell-derived factor involved in the regulation of the spatial arrangement of cells during vascular tube assembly. With its impact on tubulogenesis and vessel shape EGFL7 joined the large family of molecules governing blood vessel formation. EGFL7 regulates midline angioblast migration in zebrafish embryos-a key step in vascular tubulogenesis. EGFL7 is tightly associated with the extracellular matrix (ECM), and it supports EC migration either as a single factor or in combination with other ECM molecules. EGFL7 provides a proper microenvironment for endothelial cell migration, thereby enabling accurate patterning. Our study indicates that the molecular composition of the ECM influences vascular morphogenesis. EGFL7 also regulates vascular tubulogenesis. It inhibits platelet-derived growth factor (PDGF)-BB-induced smooth muscle cell migration and promotes endothelial cells adhesion to the substrate.
Product Memo NEU1 Protein, Human;VE-STATIN Protein, Human;ZNEU1 Protein, Human
Product Type Recombinant Protein
Purity Greater than 92% as determined by SDS-PAGE
Source Baculovirus-Insect Cells
Storage Store recombinant protein under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Terminal His
Usage Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use