Recombinant EGFR Protein, Rat (His Tag)
The product is for non-human research only. Not for therapeutic or veterinary use.
Catalog No: bt-203178
Molecular Weight: The recombinant rat EGFR comprises 633a.a and predicts a molecular weight of 70.7 kDa. The apparent molecular weight of the recombinant protein is approximately 93-110 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Formulation: Recombinant EGFR Protein was lyophilized from sterile PBS, pH 7.41
Source: HEK293 Cells
|Product Name||Recombinant EGFR Protein, Rat (His Tag)|
|Molecular Weight||The recombinant rat EGFR comprises 633a.a and predicts a molecular weight of 70.7 kDa. The apparent molecular weight of the recombinant protein is approximately 93-110 kDa in SDS-PAGE under reducing conditions due to glycosylation.|
|Bioactivity||1. Measured by its ability to bind recombinant human EGF-Fc in a functional ELISA.2. Measured by its ability to bind recombinant mouse EGF-Fc in a functional ELISA.|
|Formulation||Recombinant EGFR Protein was lyophilized from sterile PBS, pH 7.41|
|Description||The rat EGFR (E7CXR8) (Met1-Ser646) was expressed, fused with a polyhistidine tag at the C-terminus|
|Product Background||As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR protein plays a crucial role in signaling pathway in the regulation of cell proliferation, survival and differentiation. Binding of a ligand induces EGFR protein homo- or heterodimerization, the subsequent tyrosine autophosphorylation and initiates various down stream pathways (MAPK, PI3K/PKB and STAT). In addition, EGFR signaling also has been shown to exert action on carcinogenesis and disease progression, and thus EGFR protein is proposed as a target for cancer therapy currently.Immune CheckpointImmunotherapyCancer ImmunotherapyTargeted Therapy|
|Product Type||Recombinant Protein|
|Purity||Greater than 98% as determined by SDS-PAGE|
|Storage||Store recombinant protein under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.|
|Usage||Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use|