Recombinant EDA2R Protein, Cynomolgus (Fc Tag) Recombinant Proteins The cynomolgus EDA2R (NP_001180396.1) (Met1-Glu136) was expressed with the Fc region of human IgG1 at the C-terminus The recombinant cynomolgus EDA2R is a disulfide-linked homodimer. The reduced monomer comprises 377a.a and has a calculated molecular weight of 42.1 KDa.The apparent molecular weight of the protein is approximately 116, 58 and 53 KDa respectively in SDS-PAGE.
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Formulation: The recombinant cynomolgus EDA2R is a disulfide-linked homodimer. The reduced monomer comprises 377a.a and has a calculated molecular weight of 42.1 KDa.The apparent molecular weight of the protein is approximately 116, 58 and 53 KDa respectively in SDS-PAGE.
Source: HEK293 Cells
Usage: Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use

Recombinant EDA2R Protein, Cynomolgus (Fc Tag)

The product is for non-human research only. Not for therapeutic or veterinary use.

Catalog Number: BT-203211

Molecular Weight: The recombinant cynomolgus EDA2R is a disulfide-linked homodimer. The reduced monomer comprises 377a.a and has a calculated molecular weight of 42.1 KDa.The apparent molecular weight of the protein is approximately 116, 58 and 53 KDa respectively in SDS-PAGE.

Formulation: Recombinant EDA2R Protein was lyophilized from sterile PBS, pH 7.4.1

Source: HEK293 Cells

Product Name Recombinant EDA2R Protein, Cynomolgus (Fc Tag)
Molecular Weight The recombinant cynomolgus EDA2R is a disulfide-linked homodimer. The reduced monomer comprises 377a.a and has a calculated molecular weight of 42.1 KDa.The apparent molecular weight of the protein is approximately 116, 58 and 53 KDa respectively in SDS-PAGE.
AA Sequence Met1-Glu136
Bioactivity Please contact us for detailed information
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method
Formulation Recombinant EDA2R Protein was lyophilized from sterile PBS, pH 7.4.1
Host Species Cynomolgus
Description The cynomolgus EDA2R (NP_001180396.1) (Met1-Glu136) was expressed with the Fc region of human IgG1 at the C-terminus
Product Background Tumor necrosis factor receptor superfamily member 27, also known as X-linked ectodysplasin-A2 receptor, EDA-A2 receptor, EDA2R, XEDAR and TNFRSF27, is a single-pass type III membrane protein. TNFRSF27 / EDA2R contains threeTNFR-Cys repeats. It is a new member of the tumor necrosis factor receptor family that has been shown to be highly expressed in ectodermal derivatives during embryonic development and binds to ectodysplasin-A2 (EDA-A2). TNFRSF27 / EDA2R is a receptor for EDA isoform A2, but not for EDA isoform A1. TNFRSF27 / EDA2R mediates the activation of the NF-kappa-B and JNK pathways. The activation seems to be mediated by binding to TRAF3 and TRAF6. Ectodysplasin, a member of the tumor necrosis factor family, is encoded by the anhidrotic ectodermal dysplasia EDA gene. Mutations in EDA give rise to a clinical syndrome characterized by loss of hair, sweat glands, and teeth. EDA-A1 and EDA-A2 are two isoforms of ectodysplasin that differ only by an insertion of two amino acids. This insertion functions to determine receptor binding specificity, such that EDA-A1 binds only the receptor EDAR, whereas EDA-A2 binds only the related, but distinct, X-linked ectodysplasin-A2 receptor (XEDAR).
Product Type Recombinant Protein
Purity (60.3+19.2+15)% as determined by SDS-PAGE
Source HEK293 Cells
Storage Store recombinant protein under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Terminal Met
Usage Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use
Last Modified Aug 20 2021