Recombinant DR6 Protein, Rat (Fc Tag) Recombinant Proteins The rat TNFRSF21 (NP_001101677.1) extracellular domain (Met 1-His 349) was fused with the Fc region of human IgG1 at the C-terminus The recombinant rat TNFRSF21 comprises 549a.a and predicts a molecular weight of 60.5 kDa.
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Formulation: The recombinant rat TNFRSF21 comprises 549a.a and predicts a molecular weight of 60.5 kDa.
Source: HEK293 Cells
Usage: Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use

Recombinant DR6 Protein, Rat (Fc Tag)

The product is for non-human research only. Not for therapeutic or veterinary use.

Catalog Number: BT-203225

Molecular Weight: The recombinant rat TNFRSF21 comprises 549a.a and predicts a molecular weight of 60.5 kDa.

Formulation: Recombinant DR6 Protein was lyophilized from sterile PBS, pH 7.41

Source: HEK293 Cells

Product Name Recombinant DR6 Protein, Rat (Fc Tag)
Molecular Weight The recombinant rat TNFRSF21 comprises 549a.a and predicts a molecular weight of 60.5 kDa.
AA Sequence Met 1-His 349
Bioactivity Please contact us for detailed information
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method
Formulation Recombinant DR6 Protein was lyophilized from sterile PBS, pH 7.41
Host Species Rat
Description The rat TNFRSF21 (NP_001101677.1) extracellular domain (Met 1-His 349) was fused with the Fc region of human IgG1 at the C-terminus
Product Background TNFRSF21 (death receptor-6, DR6) is an orphan TNF receptor superfamily member and belongs to a subgroup of receptors called death receptors. This type I transmembrane receptor possesses four extracellular cysteine-rich motifs and a cytoplasmic death domain. DR6 is an extensively posttranslationally modified transmembrane protein and that N- and O-glycosylations of amino acids in its extracellular part. DR6 interacts with the adaptor protein TRADD and mediates signal transduction through its death domain, and expression of DR6 in mammalian cells induces activation of both NF-kappaB and JNK and cell apoptosis. DR6 knockout mice have enhanced CD4+ T cell proliferation and Th2 cytokine production, suggested that DR6 serves as an important regulatory molecule in T-helper cell activation, and is involved in inflammation and immune regulation. DR6 is expressed ubiquitously with high expression in lymphoid organs, heart, brain and pancreas. Some tumor cells overexpress DR6, typically in conjunction with elevated anti-apoptosis molecules. DR6 may also be involved in tumor cell survival and immune evasion, which is subject to future investigations.
Product Type Recombinant Protein
Purity Greater than (72.9+15.6+5.2)% as determined by SDS-PAGE
Source HEK293 Cells
Storage Store recombinant protein under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Terminal Gln 42
Usage Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use
Last Modified Aug 20 2021