Recombinant DR5 Protein, Mouse (His & Fc Tag) Recombinant Proteins The extracellular domain of mouse TNFRSF10B (NP_064671.2) (Met 1-Ser 177) was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus The recombinant mouse TNFRSF10B/Fc chimera is a disulfide-linked homodimer. The reduced monomer consists of 373a.a and has a calculated molecular weight of 41.8 kDa. As a result of glycosylation, the apparent molecular weight of the TNFRSF10B/Fc monomer is approximately 50-55 kDa in SDS-PAGE under r
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Formulation: The recombinant mouse TNFRSF10B/Fc chimera is a disulfide-linked homodimer. The reduced monomer consists of 373a.a and has a calculated molecular weight of 41.8 kDa. As a result of glycosylation, the apparent molecular weight of the TNFRSF10B/Fc monomer is approximately 50-55 kDa in SDS-PAGE under r
Source: HEK293 Cells
Usage: Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use

Recombinant DR5 Protein, Mouse (His & Fc Tag)

The product is for non-human research only. Not for therapeutic or veterinary use.

Catalog Number: BT-203257

Molecular Weight: The recombinant mouse TNFRSF10B/Fc chimera is a disulfide-linked homodimer. The reduced monomer consists of 373a.a and has a calculated molecular weight of 41.8 kDa. As a result of glycosylation, the apparent molecular weight of the TNFRSF10B/Fc monomer is approximately 50-55 kDa in SDS-PAGE under r

Formulation: Recombinant DR5 Protein was lyophilized from sterile PBS, pH 7.41

Source: HEK293 Cells

Product Name Recombinant DR5 Protein, Mouse (His & Fc Tag)
Molecular Weight The recombinant mouse TNFRSF10B/Fc chimera is a disulfide-linked homodimer. The reduced monomer consists of 373a.a and has a calculated molecular weight of 41.8 kDa. As a result of glycosylation, the apparent molecular weight of the TNFRSF10B/Fc monomer is approximately 50-55 kDa in SDS-PAGE under r
AA Sequence Met 1-Ser 177
Bioactivity 1. Immobilized human TNFSF10 at 10 ug/ml (100 ul/well) can bind mouse TNFRSF10B-Fch, The EC50 of mouse TNFRSF10B-Fch is 0.07-0.17 ug/ml.2. Measured by its ability to inhibit TRAIL-mediated cytotoxicity using L‑929 mouse fibroblast cells treated with TRAIL. The ED50 for this effect is typically 20-80 ng/ml in the presence of 20 ng/ml Recombinant Human TRAIL/TNFSF10.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method
Formulation Recombinant DR5 Protein was lyophilized from sterile PBS, pH 7.41
Host Species Mouse
Description The extracellular domain of mouse TNFRSF10B (NP_064671.2) (Met 1-Ser 177) was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus
Product Background Tumor necrosis factor receptor superfamily, member 1b, official symbol TNFRSF1B, also known as Death receptor 5, CD262, TNF-related apoptosis-inducing ligand receptor 2 (TRAIL R2), is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF1/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. TRAIL R2/CD262/TNFRSF1B was purified independently as the only receptor for TRAIL detectable on the surface of two different human cell lines that undergo apoptosis upon stimulation with TRAIL. TRAIL R2/CD262/TNFRSF1B contains two extracellular cysteine-rich repeats, typical for TNF receptor (TNFR) family members, and a cytoplasmic death domain. TRAIL R2/CD262/TNFRSF1B mediates apoptosis via the intracellular adaptor molecule FADD/MORT1. TRAIL receptors can signal both death and gene transcription, functions reminiscent of those of TNFR1 and TRAMP, two other members of the death receptor family. Defects in TRAIL R2/CD262/TNFRSF1B may be a cause of head and neck squamous cell carcinomas (HNSCC) also known as squamous cell carcinoma of the head and neck.Immune CheckpointImmunotherapyCancer ImmunotherapyTargeted Therapy
Product Memo DR5 Protein, Mouse;KILLER Protein, Mouse;Ly98 Protein, Mouse;MK Protein, Mouse;TRAILR2 Protein, Mouse;TRICK2A Protein, Mouse;TRICK2B Protein, Mouse;TRICKB Protein, Mouse
Product Type Recombinant Protein
Purity Greater than 95% as determined by SDS-PAGE
Source HEK293 Cells
Storage Store recombinant protein under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Terminal Asn 53
Usage Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use
Last Modified Aug 20 2021