Recombinant DMBT1 Protein, Human (His Tag) Recombinant Proteins The N-terminal segment of human DMBT1 (NP_004397.2) (Met 1-Ser 220) was expressed, fused with a polyhistidine tag at the C-terminus The recombinant human DMBT1 consists of 211a.a and has a predicted molecular weight of 22.6 kDa. The apparent molecular weight of rh DMBT1 is approximately 35-45 kDa in SDS-PAGE under reducing conditions due to glycosylation.
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Formulation: The recombinant human DMBT1 consists of 211a.a and has a predicted molecular weight of 22.6 kDa. The apparent molecular weight of rh DMBT1 is approximately 35-45 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Source: HEK293 Cells
Usage: Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use

Recombinant DMBT1 Protein, Human (His Tag)

Formulation: Recombinant DMBT1 Protein was lyophilized from sterile PBS, pH 7.41

Source: HEK293 Cells

Product Name Recombinant DMBT1 Protein, Human (His Tag)
Product Type Recombinant Protein
Source HEK293 Cells
Formulation Recombinant DMBT1 Protein was lyophilized from sterile PBS, pH 7.41
Molecular Weight The recombinant human DMBT1 consists of 211a.a and has a predicted molecular weight of 22.6 kDa. The apparent molecular weight of rh DMBT1 is approximately 35-45 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method
Purity Greater than 95% as determined by SDS-PAGE
Description The N-terminal segment of human DMBT1 (NP_004397.2) (Met 1-Ser 220) was expressed, fused with a polyhistidine tag at the C-terminus
Host Species Homo sapiens (Human)
Usage Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use
Storage Store recombinant protein under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
AA Sequence Met 1-Ser 220
Product Background Deleted in malignant brain tumors 1 protein, also known as glycoprotein 34, surfactant pulmonary-associated D-binding protein, DMBT1 and GP34, is a secreted protein which belongs to theDMBT1 family. DMBT1 contains 2CUB domains, 14SRCR domains and 1ZP domain. It is highly expressed in alveolar and macrophage tissues. In some macrophages, expression is detected on the membrane, and in other macrophages, it is strongly expressed in the phagosome/phagolysosome compartments. Defects in DMBT1 are involved in the development of glioma (GLM). Gliomas are central nervous system neoplasms derived from glial cells and comprise astrocytomas, glioblastoma multiforme, oligodendrogliomas , and ependymomas. DMBT1 may be considered as a candidate tumor suppressor for brain, lung, esophageal, gastric, and colorectal cancers. It may play roles in mucosal defense system, cellular immune defense and epithelial differentiation. DMBT1 may play a role as an opsonin receptor for SFTPD and SPAR in macrophage tissues throughout the body, including epithelial cells lining the gastrointestinal tract. It may be an important factor in fate decision and differentiation of transit-amplifying ductular (oval) cells within the hepatic lineage. DMBT1 may function as a binding protein in saliva for the regulation of taste sensation. It binds to HIV-1 envelope protein and has been shown to both inhibit and facilitate viral transmission.
Memo GP340 Protein, Human;muclin Protein, Human
Terminal Gly 21
Bioactivity 1. Measured by its binding ability in a functional ELISA.2. Immobilized recombinant human Galectin-3 at 10 ug/ml (100 ul/well) can bind biotinylated DMBT1-His with a linear range of 0.06-1.0 ug/ml.