Recombinant DMP1 Protein, Human (His Tag) Recombinant Proteins The human DMP1 (Q13316-1) (Met 1-Tyr 513) was expressed, with a polyhistidine tag at the C-terminus The recombinant human DMP1 consists of 508a.a and predictes a molecular weight of 55.4 kDa. In SDS-PAGE under reducing conditions, the apparent molecular weight of rhDMP1 is approximately 53 kDa.
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Formulation: The recombinant human DMP1 consists of 508a.a and predictes a molecular weight of 55.4 kDa. In SDS-PAGE under reducing conditions, the apparent molecular weight of rhDMP1 is approximately 53 kDa.
Source: HEK293 Cells
Usage: Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use

Recombinant DMP1 Protein, Human (His Tag)

The product is for non-human research only. Not for therapeutic or veterinary use.

Catalog Number: BT-203274

Molecular Weight: The recombinant human DMP1 consists of 508a.a and predictes a molecular weight of 55.4 kDa. In SDS-PAGE under reducing conditions, the apparent molecular weight of rhDMP1 is approximately 53 kDa.

Formulation: Recombinant DMP1 Protein was lyophilized from sterile PBS, pH 7.41

Source: HEK293 Cells

Product Name Recombinant DMP1 Protein, Human (His Tag)
Molecular Weight The recombinant human DMP1 consists of 508a.a and predictes a molecular weight of 55.4 kDa. In SDS-PAGE under reducing conditions, the apparent molecular weight of rhDMP1 is approximately 53 kDa.
AA Sequence Met 1-Tyr 513
Bioactivity Measured by its ability to bind human CFH in a functional ELISA.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method
Formulation Recombinant DMP1 Protein was lyophilized from sterile PBS, pH 7.41
Host Species Homo sapiens (Human)
Description The human DMP1 (Q13316-1) (Met 1-Tyr 513) was expressed, with a polyhistidine tag at the C-terminus
Product Background Dentin matrix acidic phosphoprotein (DMP1) is an extracellular matrix protein and a member of the small integrin binding ligand N-linked glycoprotein family. This protein, which is critical for proper mineralization of bone and dentin, is present in diverse cells of bone and tooth tissues. DMP1 contains a large number of acidic domains, multiple phosphorylation sites, a functional arg-gly-asp cell attachment sequence, and a DNA binding domain. In undifferentiated osteoblasts it is primarily a nuclear protein that regulates the expression of osteoblast-specific genes. During osteoblast maturation, DMP1 becomes phosphorylated and is exported to the extracellular matrix, where it orchestrates mineralized matrix formation. Mutations in DMP1 are known to cause autosomal recessive hypophosphatemia, a disease that manifests as rickets and osteomalacia. DMP1 may have a dual function during osteoblast differentiation. In the nucleus of undifferentiated osteoblasts, unphosphorylated form acts as a transcriptional component for activation of osteoblast-specific genes like osteocalcin. During the osteoblast to osteocyte transition phase it is phosphorylated and exported into the extracellular matrix, where it regulates nucleation of hydroxyapatite.
Product Memo ARHP Protein, Human;ARHR Protein, Human;DMP-1 Protein, Human
Product Type Recombinant Protein
Purity Greater than 85% as determined by SDS-PAGE
Source HEK293 Cells
Storage Store recombinant protein under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Terminal Leu 17
Uniprot No Q13316
Usage Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use
Last Modified Aug 20 2021