Recombinant CXCL1 Protein, Human (His & SUMO Tag)
Recombinant Proteins
The mature form of human CXCL1 (P09341-1) (Ala 35-Asn 107) was fused with a N-terminal polyhistide-tagged SUMO tag at the N-terminus
The recombinant human CXCL1 consisting of 189a.a and has a calculated molecular weight of 21.3 kDa. It migrates as an 30 kDa band in SDS-PAGE under reducing conditions.
Formulation:
The recombinant human CXCL1 consisting of 189a.a and has a calculated molecular weight of 21.3 kDa. It migrates as an 30 kDa band in SDS-PAGE under reducing conditions.
Source:
E. coli
Usage:
Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use
Recombinant CXCL1 Protein, Human (His & SUMO Tag)
The product is for non-human research only. Not for therapeutic or veterinary use.
Catalog No: bt-203381
Molecular Weight: The recombinant human CXCL1 consisting of 189a.a and has a calculated molecular weight of 21.3 kDa. It migrates as an 30 kDa band in SDS-PAGE under reducing conditions.
Formulation: Recombinant CXCL1 Protein was lyophilized from sterile PBS, pH 7.4, 10% glycerol1
Source: E. coli
| Product Name | Recombinant CXCL1 Protein, Human (His & SUMO Tag) |
|---|---|
| AA Sequence | Ala 35-Asn 107 |
| Bioactivity | Please contact us for detailed information |
| Description | The mature form of human CXCL1 (P09341-1) (Ala 35-Asn 107) was fused with a N-terminal polyhistide-tagged SUMO tag at the N-terminus |
| Formulation | Recombinant CXCL1 Protein was lyophilized from sterile PBS, pH 7.4, 10% glycerol1 |
| Host Species | Homo sapiens (Human) |
| Molecular Weight | The recombinant human CXCL1 consisting of 189a.a and has a calculated molecular weight of 21.3 kDa. It migrates as an 30 kDa band in SDS-PAGE under reducing conditions. |
| Product Background | The Chemokine (C-X-C motif) Ligand 1, CXCL1, is a small cytokine belonging to the CXC chemokine family that was previously called GRO1 oncogene, GRO?, KC, Neutrophil-activating protein 3 (NAP-3) and melanoma growth stimulating activity, alpha (MSGA-a). CXCL1 already known to be important in osteoarthritis (OA), as a novel target gene of transcription factor AP-2? in chondrocytes and support the important role of AP-2? in cartilage. CXCL1 is a potent neutrophil chemoattractant with recognized roles in angiogenesis and inflammation. CXCL1 is a novel immediate PTH/PTHrP-responsive gene. CXCL1 may act as a chemoattractant for osteoclast precursors. CXCL1 may also have important pro-nociceptive effects via its direct actions on sensory neurons, and may induce long-term changes that involve protein synthesis. CXCL1 plays a critical nonredundant role in the development of experimental Lyme arthritis and carditis via CXCR2-mediated recruitment of neutrophils into the site of infection. CXCL1 functions through CXCR2 to transactivate the EGFR by proteolytic cleavage of HB-EGF, leading to activation of MAPK signalling and increased proliferation of epithelial ovarian cancer (EOC) cells. It might limit tumor growth by reinforcing senescence early in tumorigenesis. Thus, CXCL1 plays a role in spinal cord development by inhibiting the migration of oligodendrocyte precursors and is involved in the processes of angiogenesis, inflammation, wound healing, and tumorigenesis. |
| Product Memo | CA21H Protein, Human;CAH1 Protein, Human;CPS1 Protein, Human;CYP21 Protein, Human;CYP21B Protein, Human;FSP Protein, Human;GRO1 Protein, Human;GROa Protein, Human;MGSA Protein, Human;MGSA-a Protein, Human;NAP-3 Protein, Human;P450c21B Protein, Human; |
| Product Type | Recombinant Protein |
| Purity | Greater than 97% as determined by SDS-PAGE |
| Source | E. coli |
| Storage | Store recombinant protein under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
| Terminal | Met |
| Uniprot No | P09341 |
| Usage | Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use |