Recombinant CTLA-4 Protein, Mouse (His Tag) Recombinant Proteins The extracellular domain of mouse CTLA4 (NP_033973.2) (Met 1-Phe 162) was expressed, with a polyhistidine tag at the C-terminus The recombinant mouse CTLA4 consists of 138a.a and has a predicted molecular weight of 15.3 kDa. In SDS-PAGE under reducing conditions, the apparent molecular weight of rm CTLA4 is approximately 25-30 kDa due to glycosylation.
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Formulation: The recombinant mouse CTLA4 consists of 138a.a and has a predicted molecular weight of 15.3 kDa. In SDS-PAGE under reducing conditions, the apparent molecular weight of rm CTLA4 is approximately 25-30 kDa due to glycosylation.
Source: HEK293 Cells
Usage: Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use

Recombinant CTLA-4 Protein, Mouse (His Tag)

Formulation: Recombinant CTLA-4 Protein was lyophilized from sterile PBS, pH 7.41

Source: HEK293 Cells

Product Name Recombinant CTLA-4 Protein, Mouse (His Tag)
Product Type Recombinant Protein
Source HEK293 Cells
Formulation Recombinant CTLA-4 Protein was lyophilized from sterile PBS, pH 7.41
Molecular Weight The recombinant mouse CTLA4 consists of 138a.a and has a predicted molecular weight of 15.3 kDa. In SDS-PAGE under reducing conditions, the apparent molecular weight of rm CTLA4 is approximately 25-30 kDa due to glycosylation.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method
Purity Greater than 98% as determined by SDS-PAGE
Description The extracellular domain of mouse CTLA4 (NP_033973.2) (Met 1-Phe 162) was expressed, with a polyhistidine tag at the C-terminus
Host Species Mouse
Usage Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use
Storage Store recombinant protein under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
AA Sequence Met 1-Phe 162
Product Background Cytotoxic T-lymphocyte protein 4, also known as CTLA4 and CD152, is a single-pass type I membrane protein and a member of the immunoglobulin superfamily. It is the second member of the CD28 receptor family. The ligands or counterreceptors for these two proteins are the B7 family members, CD8 (B7-1) and CD86 (B7-2). CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may play an important role in their functions. CD152 or cytotoxic T lymphocyte antigen-4 (CTLA-4) is an essential receptor involved in the negative regulation of T cell activation. Because of its profound inhibitory role, CD152 has been considered a sound susceptible candidate in autoimmunity and a persuasive target for cancer immunotherapy. In particular, recent evidence suggests that CD152 is also important in the homeostasis and function of a population of suppressive cells, termed regulatory T cells (Treg).Immune CheckpointImmune Checkpoint Detection: AntibodiesImmune Checkpoint Detection: ELISA AntibodiesImmune Checkpoint Detection: IP AntibodiesImmune Checkpoint Detection: WB AntibodiesImmune Checkpoint ProteinsCTLA4 / CD152 Immune Checkpoint ProteinsImmune Checkpoint TargetsCo-inhibitory Immune Checkpoint Targets ImmunotherapyCancer ImmunotherapyTargeted Therapy
Memo Cd152 Protein, Mouse;Ctla-4 Protein, Mouse;Ly-56 Protein, Mouse
Terminal Glu 36
Bioactivity 1. Measured by its binding ability in a functional ELISA.2. Immobilized recombinant mouse CTLA4-His at 10 ug/ml (100 ul/well) can mouse CD80-Fc with a linear range of 0.78-62.5 ng/ml.3. Immobilized recombinant mouse CTLA4-His at 10 ug/ml (100 ul/well) can human B7-1-Fc with a linear range of 0.78-125 ng/ml.