Recombinant CD70 Protein, Mouse (Fc Tag) Recombinant Proteins The mouse Cd70 (NP_035747.1) (Gln47-Pro195) was expressed with the Fc region of mouse IgG1 at the N-terminus The recombinant mouse Cd70 consists 385a.a and predicts a molecular weight of 43.1 kDa.
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Formulation: The recombinant mouse Cd70 consists 385a.a and predicts a molecular weight of 43.1 kDa.
Source: HEK293 Cells
Usage: Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use

Recombinant CD70 Protein, Mouse (Fc Tag)

Formulation: Recombinant CD70 Protein was lyophilized from sterile PBS, pH 7.4.1

Source: HEK293 Cells

Product Name Recombinant CD70 Protein, Mouse (Fc Tag)
Product Type Recombinant Protein
Source HEK293 Cells
Formulation Recombinant CD70 Protein was lyophilized from sterile PBS, pH 7.4.1
Molecular Weight The recombinant mouse Cd70 consists 385a.a and predicts a molecular weight of 43.1 kDa.
Endotoxin < 1.0 EU per μg protein as determined by the LAL method
Purity Greater than (12.5+86.3)% as determined by SDS-PAGE.
Description The mouse Cd70 (NP_035747.1) (Gln47-Pro195) was expressed with the Fc region of mouse IgG1 at the N-terminus
Host Species Mouse
Usage Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use
Storage Store recombinant protein under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
AA Sequence Gln47-Pro195
Product Background CD7, a member of the tumor necrosis factor superfamily, is restricted to activated T-and B-lymphocytes and mature dendritic cells. Binding of CD7 to its receptor, CD27, is important in priming, effector functions, differentiation and memory formation of T-cells as well as plasma and memory B-cell generation. Tight control of CD7 expression is required to prevent lethal immunodeficiency. By selective transcription, CD7 is largely confined to activated lymphocytes and dendritic cells (DC). As a type II transmembrane receptor, CD7 is normally expressed on a subset of B, T and NK cells, where it plays a costimulatory role in immune cell activation. Immunohistochemical analysis of CD7 expression in multiple carcinoma types. The restricted expression pattern of CD7 in normal tissues and its widespread expression in various malignancies makes it an attractive target for antibody-based therapeutics. Investigations to exploit CD7 as a cancer target have lead to the identification of potential antibody-based clinical candidates.Immune CheckpointImmune Checkpoint ProteinsImmune Checkpoint TargetsCo-stimulatory Immune Checkpoint Targets ImmunotherapyCancer ImmunotherapyTargeted Therapy
Memo Cd27l Protein, Mouse;CD27LG Protein, Mouse;Tnfsf7 Protein, Mouse
Terminal Asp
Bioactivity 1.Measured by its binding ability in a functional ELISA.2.Immobilized mouse CD27-His(Cat 50110-M08H) at 10ug/mL (100uL/well) can bind mouse CD70, the EC50 of mouse CD70 is 10-50 ng/mL.