Recombinant CD42c Protein, Rat (Fc Tag) Recombinant Proteins The rat GP1BB (Q9JJM7) (Met1-Cys147) was expressed, fused with the Fc region of human IgG1 at the C-terminus The recombinant rat GP1BB/Fc is a disulfide-linked homodimer. The reduced monomer comprises 359a.a and has a predicted molecular weight of 40.1 kDa. The apparent molecular weight of the protein is approximately 63 kDa in SDS-PAGE under reducing conditions.
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Formulation: The recombinant rat GP1BB/Fc is a disulfide-linked homodimer. The reduced monomer comprises 359a.a and has a predicted molecular weight of 40.1 kDa. The apparent molecular weight of the protein is approximately 63 kDa in SDS-PAGE under reducing conditions.
Source: HEK293 Cells
Usage: Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use

Recombinant CD42c Protein, Rat (Fc Tag)

Formulation: Recombinant CD42c Protein was lyophilized from sterile PBS, pH 7.41

Source: HEK293 Cells

Product Name Recombinant CD42c Protein, Rat (Fc Tag)
Product Type Recombinant Protein
Source HEK293 Cells
Formulation Recombinant CD42c Protein was lyophilized from sterile PBS, pH 7.41
Molecular Weight The recombinant rat GP1BB/Fc is a disulfide-linked homodimer. The reduced monomer comprises 359a.a and has a predicted molecular weight of 40.1 kDa. The apparent molecular weight of the protein is approximately 63 kDa in SDS-PAGE under reducing conditions.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method
Purity Greater than 85% as determined by SDS-PAGE
Description The rat GP1BB (Q9JJM7) (Met1-Cys147) was expressed, fused with the Fc region of human IgG1 at the C-terminus
Host Species Rat
Usage Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use
Storage Store recombinant protein under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
AA Sequence Met1-Cys147
Product Background Platelet glycoprotein Ib (GPIb) complex is best known as a major platelet receptor for von Willebrand factor essential for platelet adhesion under high shear conditions found in arteries and in thrombosis. The GPIb complex is composed of GPIb alpha (Platelet glycoprotein Ib alpha chain) covalently attached to GPIb beta (Platelet glycoprotein Ib beta chain) and noncovalently complexed with GPIX and GPV. GPIb-beta, also known as GP1BB, CD42b-beta and CD42c, is single-pass type I membrane protein expressed in heart and brain, which is a critical component of the von Willebrand factor (vWF) receptor. The cysteine knot region of GPIb beta in the N terminus is critical for the conformation of GPIb beta that interacts with GPIX. The precursor of GP1BB is synthesized from a 1. kb mRNA expressed in plateletes and megakaryocytes. GPIb is a heterodimeric transmembrane protein consisting of a disulfide-linked 14 kD alpha chain and 22 kD beta chain. GPIb alpha chain provides the vWF binding site, and GPIb beta chain contributes to surface expression of the receptor and participates in transmembrane signaling through phosphorylation of its intracellular domain. GP1BB is part of the GPIb-V-IX system that constitutes the receptor for von Willebrand factor (vWF), and mediates platelet adhesion in the arterial circulation. Defects in GP1BB are a cause of Bernard-Soulier syndrome (BSS), also known as giant platelet disease (GPD). BSS patients have unusually large platelets and have a clinical bleeding tendency.
Uniprot Number Q9JJM7
Terminal Pro 27
Bioactivity Please contact us for detailed information