Recombinant CD44 Protein, Human (Fc Tag) Recombinant Proteins The human CD44 (P16070-1) (Met1-Pro220) was expressed with the Fc region of human IgG1 at the C-terminus The recombinant human CD44/Fc is a disulfide-linked homodimer. The reduced monomer comprises 441a.a and has a predicted molecular weight of 49.1 kDa. The apparent molecular weight of the protein is approximately 76 kDa in SDS-PAGE under reducing conditions.
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Formulation: The recombinant human CD44/Fc is a disulfide-linked homodimer. The reduced monomer comprises 441a.a and has a predicted molecular weight of 49.1 kDa. The apparent molecular weight of the protein is approximately 76 kDa in SDS-PAGE under reducing conditions.
Source: HEK293 Cells
Usage: Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use

Recombinant CD44 Protein, Human (Fc Tag)

Formulation: Recombinant CD44 Protein was lyophilized from sterile PBS, pH 7.4.1

Source: HEK293 Cells

Product Name Recombinant CD44 Protein, Human (Fc Tag)
Product Type Recombinant Protein
Source HEK293 Cells
Formulation Recombinant CD44 Protein was lyophilized from sterile PBS, pH 7.4.1
Molecular Weight The recombinant human CD44/Fc is a disulfide-linked homodimer. The reduced monomer comprises 441a.a and has a predicted molecular weight of 49.1 kDa. The apparent molecular weight of the protein is approximately 76 kDa in SDS-PAGE under reducing conditions.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method
Purity Greater than 90% as determined by SDS-PAGE
Description The human CD44 (P16070-1) (Met1-Pro220) was expressed with the Fc region of human IgG1 at the C-terminus
Host Species Homo sapiens (Human)
Usage Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use
Storage Store recombinant protein under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
AA Sequence Met1-Pro220
Product Background CD44 is a type I transmembrane protein and a member of the cartilage link protein family. It is involved in cell-cell and cell-matrix interactions and signal transduction. Several CD44 ligands have been identified. The most extensively characterized ligand for CD44 is hyaluronan, a component of the extracellular matrix. CD44 protein is expressed on the majority of immune cells. The binding of CD44 to hyaluronan is induced on T lymphocytes after activation by antigen and on monocytes after stimulation by inflammatory agents. Under inflammatory conditions, CD44 on endothelial cells presents hyaluronan to CD44 on activated T lymphocytes and mediates a rolling interaction under flow conditions. Perturbations of the hyaluronan-CD44 interaction at the plasma membrane by various antagonists result in attenuation of receptor tyrosine kinase and transporter activities and inhibition of tumor progression in vivo. CD44 is known to interact with the ezrin family (ERM family) members and form a complex that plays diverse roles within both normal and abnormal cells, particularly cancer cells. CD44 and ezrin and their respective complex have properties suggesting that they may be important in the process of tumour-endothelium interactions, cell migrations, cell adhesion, tumour progression and metastasis.
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Uniprot Number P16070
Terminal Gln 21
Bioactivity Please contact us for detailed information