Recombinant CD22 Protein, Mouse (Fc Tag) Recombinant Proteins The mouse CD22 (BAE33829.1)(Met1-Arg708) was expressed with the Fc region of human IgG1 at the C-terminus The recombinant mouse CD22/Fc is a disulfide-linked homodimer. The reduced monomer comprises 931a.a and has a predicted molecular weight of 104.3 kDa. The apparent molecular weight of the protein is approximately 125 kDa in SDS-PAGE under reducing conditions.
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Formulation: The recombinant mouse CD22/Fc is a disulfide-linked homodimer. The reduced monomer comprises 931a.a and has a predicted molecular weight of 104.3 kDa. The apparent molecular weight of the protein is approximately 125 kDa in SDS-PAGE under reducing conditions.
Source: HEK293 Cells
Usage: Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use

Recombinant CD22 Protein, Mouse (Fc Tag)

Formulation: Recombinant CD22 Protein was lyophilized from sterile PBS, pH 7.4.1

Source: HEK293 Cells

Product Name Recombinant CD22 Protein, Mouse (Fc Tag)
Product Type Recombinant Protein
Source HEK293 Cells
Formulation Recombinant CD22 Protein was lyophilized from sterile PBS, pH 7.4.1
Molecular Weight The recombinant mouse CD22/Fc is a disulfide-linked homodimer. The reduced monomer comprises 931a.a and has a predicted molecular weight of 104.3 kDa. The apparent molecular weight of the protein is approximately 125 kDa in SDS-PAGE under reducing conditions.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method
Purity Greater than 95% as determined by SDS-PAGE
Description The mouse CD22 (BAE33829.1)(Met1-Arg708) was expressed with the Fc region of human IgG1 at the C-terminus
Host Species Mouse
Usage Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use
Storage Store recombinant protein under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
AA Sequence Met1-Arg708
Product Background CD22 is a member of the immunoglobulin superfamily, SIGLEC family of lectins. It is first expressed in the cytoplasm of pro-B and pre-B cells, and on the surface as B cells mature to become IgD+. CD22 serves as an adhesion receptor for sialic acid-bearing ligands expressed on erythrocytes and all leukocyte classes. In addition to its potential role as a mediator of intercellular interactions, signal transduction through CD22 can activate B cells and modulate antigen receptor signaling in vitro. The phenotype of CD22-deficient mice suggests that CD22 is primarily involved in the generation of mature B cells within the bone marrow, blood, and marginal zones of lymphoid tissues. CD22 recruits the tyrosine phosphatase Src homology 2 domain-containing phosphatase 1 (SHP-1) to immunoreceptor tyrosine-based inhibitory motifs (ITIMs) and inhibits B-cell receptor (BCR)-induced Ca2+ signaling on normal B cells. CD22 interacts specifically with ligands carrying alpha2-6-linked sialic acids. As an inhibitory coreceptor of the B-cell receptor (BCR), CD22 plays a critical role in establishing signalling thresholds for B-cell activation. Like other coreceptors, the ability of CD22 to modulate B-cell signalling is critically dependent upon its proximity to the BCR, and this in turn is governed by the binding of its extracellular domain to alpha2,6-linked sialic acid ligands. However, genetic studies in mice reveal that some CD22 functions are regulated by ligand binding, whereas other functions are ligand-independent and may only require expression of an intact CD22 cytoplasmic domain at the B-cell surface. CD19 regulates CD22 phosphorylation by augmenting Lyn kinase activity, while CD22 inhibits CD19 phosphorylation via SHP-1.Immune CheckpointImmunotherapyCancer ImmunotherapyTargeted Therapy
Memo A530093D23 Protein, Mouse;Lyb-8 Protein, Mouse;Lyb8 Protein, Mouse
Terminal Arg 19
Bioactivity Please contact us for detailed information