Recombinant BTK Protein, Human (His Tag) Recombinant Proteins The human BTK (NP_000052.1) (Met 1-Ser 659) was expressed with a C-terminal polyhistidine tag The secreted recombinant human BTK consists of 670a.a and predicts a molecular weight of 77.8 KDa.
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Formulation: The secreted recombinant human BTK consists of 670a.a and predicts a molecular weight of 77.8 KDa.
Source: Baculovirus-Insect Cells
Usage: Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use

Recombinant BTK Protein, Human (His Tag)

The product is for non-human research only. Not for therapeutic or veterinary use.

Catalog No: bt-204434

Molecular Weight: The secreted recombinant human BTK consists of 670a.a and predicts a molecular weight of 77.8 KDa.

Formulation: Recombinant BTK ProteinSupplied as sterile 20mM Tris, 500mM NaCl, 10% glycerol, pH 7.0.1

Source: Baculovirus-Insect Cells

Product Name Recombinant BTK Protein, Human (His Tag)
Molecular Weight The secreted recombinant human BTK consists of 670a.a and predicts a molecular weight of 77.8 KDa.
AA Sequence Met 1-Ser 659
Bioactivity 1. The specific activity was determined to be >50 nmol/min/mg using Poly(Glu,Tyr)4 1 peptide as substrate.2. Measured by its ability to bind human BLNK in a functional ELISA.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method
Formulation Recombinant BTK ProteinSupplied as sterile 20mM Tris, 500mM NaCl, 10% glycerol, pH 7.0.1
Host Species Homo sapiens (Human)
Description The human BTK (NP_000052.1) (Met 1-Ser 659) was expressed with a C-terminal polyhistidine tag
Product Background Bruton's tyrosine kinase (or BTK) is a type of kinase protein expressed in B lymphocytes and T cells. BTK contains a PH domain which binds phosphatidylinositol(3,4,5)-trisphosphate (PIP3). After binding to PIP3, BTK is induced to phosphorylate phospholipase C, which in turn hydrolyzes PIP2 into two second messagers, IP3 and DAG, which then modulate the activity of downstream proteins during B-cell signaling. Btk is also found implicated in the primary immunodeficiency disease X-linked agammaglobulinemia(Bruton's agammaglobulinemia). BTK played a key role in B-cell maturation as well as mast cell activation through the high-affinity IgE receptor. Patients with X-linked agammaglobulinemia have normal pre-B cell populations in their bone marrow but these B-cells can not mature and enter the circulation.Immune CheckpointImmunotherapyCancer ImmunotherapyTargeted Therapy
Product Memo AGMX1 Protein, Human;AT Protein, Human;ATK Protein, Human;BPK Protein, Human;IMD1 Protein, Human;PSCTK1 Protein, Human;XLA Protein, Human
Product Type Recombinant Protein
Purity Greater than 85% as determined by SDS-PAGE
Source Baculovirus-Insect Cells
Storage Store recombinant protein under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Terminal Met
Usage Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use
Last Modified Mar 08 2019