Recombinant BTLA Protein, Mouse (Fc Tag) Recombinant Proteins The mouse BTLA (Met1-Gly176) was expressed, fused with the Fc region of human IgG1 at the C-terminus The recombinant mouse BTLA /Fc is a disulfide-linked homodimer. The reduced monomer comprises 388a.a and has a predicted molecular weight of 437 kDa. The apparent molecular weight of the protein is approximately 57-62 kDa in SDS-PAGE under reducing conditions due to glycosylation.
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Formulation: The recombinant mouse BTLA /Fc is a disulfide-linked homodimer. The reduced monomer comprises 388a.a and has a predicted molecular weight of 437 kDa. The apparent molecular weight of the protein is approximately 57-62 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Source: HEK293 Cells
Usage: Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use

Recombinant BTLA Protein, Mouse (Fc Tag)

Formulation: Recombinant BTLA Protein was lyophilized from sterile PBS, pH 7.41

Source: HEK293 Cells

Product Name Recombinant BTLA Protein, Mouse (Fc Tag)
Product Type Recombinant Protein
Source HEK293 Cells
Formulation Recombinant BTLA Protein was lyophilized from sterile PBS, pH 7.41
Molecular Weight The recombinant mouse BTLA /Fc is a disulfide-linked homodimer. The reduced monomer comprises 388a.a and has a predicted molecular weight of 437 kDa. The apparent molecular weight of the protein is approximately 57-62 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method
Purity Greater than 90% as determined by SDS-PAGE
Description The mouse BTLA (Met1-Gly176) was expressed, fused with the Fc region of human IgG1 at the C-terminus
Host Species Mouse
Usage Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use
Storage Store recombinant protein under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
AA Sequence Met1-Gly176
Product Background BTLA is a inhibitory molecule which belongs to the Ig superfamily. It down-modulates immune responses. As such, reagents that regulate the binding of BTLA to its ligand or alter BTLA signaling have significant therapeutic promise. BTLA is crucial to understand the mechanism(s) of action of these antibodies before attempting clinical applications. BTLA is not expressed by naive T cells, but it is induced during activation and remains expressed on T helper type 1 (T(H)1) but not T(H)2 cells. BTLA is a third inhibitory receptor on T lymphocytes with similarities to cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and programmed death 1 (PD-1).Immune CheckpointImmune Checkpoint TargetsCo-inhibitory Immune Checkpoint Targets ImmunotherapyCancer ImmunotherapyTargeted Therapy
Memo A630002H24 Protein, Mouse
Terminal Glu 30
Bioactivity Immobilized mouse BTLA-Fc at 10 ug/ml (100 ul/well) can bind biotinylated mouse HVEM-Fch, The EC50 of biotinylated mouse HVEM-Fch is 15.7-36.7 ng/ml.