Recombinant BTLA Protein, Rat (ECD, Fc Tag) Recombinant Proteins The rat Btla (NP_998795.1) (Ala6-Tyr183) was expressed with the Fc region of mouse IgG1 at the C-terminus The recombinant rat Btla consists 384a.a and predicts a molecular weight of 43.4 kDa.
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Formulation: The recombinant rat Btla consists 384a.a and predicts a molecular weight of 43.4 kDa.
Source: HEK293 Cells
Usage: Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use

Recombinant BTLA Protein, Rat (ECD, Fc Tag)

Formulation: Recombinant BTLA Protein was lyophilized from sterile PBS, pH 7.4.1

Source: HEK293 Cells

Product Name Recombinant BTLA Protein, Rat (ECD, Fc Tag)
Product Type Recombinant Protein
Source HEK293 Cells
Formulation Recombinant BTLA Protein was lyophilized from sterile PBS, pH 7.4.1
Molecular Weight The recombinant rat Btla consists 384a.a and predicts a molecular weight of 43.4 kDa.
Endotoxin < 1.0 EU per μg protein as determined by the LAL method
Purity Greater than 90% as determined by SDS-PAGE.
Description The rat Btla (NP_998795.1) (Ala6-Tyr183) was expressed with the Fc region of mouse IgG1 at the C-terminus
Host Species Rat
Usage Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use
Storage Store recombinant protein under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
AA Sequence Ala6-Tyr183
Product Background BTLA is a inhibitory molecule which belongs to the Ig superfamily. It down-modulates immune responses. As such, reagents that regulate the binding of BTLA to its ligand or alter BTLA signaling have significant therapeutic promise. BTLA is crucial to understand the mechanism(s) of action of these antibodies before attempting clinical applications. BTLA is not expressed by naive T cells, but it is induced during activation and remains expressed on T helper type 1 (T(H)1) but not T(H)2 cells. BTLA is a third inhibitory receptor on T lymphocytes with similarities to cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and programmed death 1 (PD-1).Immune CheckpointImmune Checkpoint TargetsCo-inhibitory Immune Checkpoint Targets ImmunotherapyCancer ImmunotherapyTargeted Therapy
Terminal Lys 30
Bioactivity 1. Measured by its binding ability in a functional ELISA.2. Immobilized rat BTLA-mFc at 10 ug/mL (100 uL/well) can bind mouse HVEM-Fch. The EC50 of mouse EFNA5-Fc is 6.2-14.4 ng/mL.