Recombinant B7-1 Protein, Human (His & Fc Tag) Recombinant Proteins The extracellular domain (Met 1-Asn 242) of human B7-1 (NP_005182.1) precursor was fused with the C-terminal His-tagged Fc region of human IgG1 at the C-terminus The recombinant human B7-1/Fc is a disulfide-linked homodimeric protein. The reduced monomer consists of 455a.a and predicts a molecular weight of 51.7 kDa. By SDS-PAGE, the apparent molecular weight of rh B7-1/Fc is approximately 80-90 kDa due to the glycosylation.
$ $99 In stock
Formulation: The recombinant human B7-1/Fc is a disulfide-linked homodimeric protein. The reduced monomer consists of 455a.a and predicts a molecular weight of 51.7 kDa. By SDS-PAGE, the apparent molecular weight of rh B7-1/Fc is approximately 80-90 kDa due to the glycosylation.
Source: HEK293 Cells
Usage: Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use

Recombinant B7-1 Protein, Human (His & Fc Tag)

The product is for non-human research only. Not for therapeutic or veterinary use.

Catalog No: bt-204561

Molecular Weight: The recombinant human B7-1/Fc is a disulfide-linked homodimeric protein. The reduced monomer consists of 455a.a and predicts a molecular weight of 51.7 kDa. By SDS-PAGE, the apparent molecular weight of rh B7-1/Fc is approximately 80-90 kDa due to the glycosylation.

Formulation: Recombinant B7-1 Protein was lyophilized from sterile PBS, pH 7.41

Source: HEK293 Cells

Product Name Recombinant B7-1 Protein, Human (His & Fc Tag)
Molecular Weight The recombinant human B7-1/Fc is a disulfide-linked homodimeric protein. The reduced monomer consists of 455a.a and predicts a molecular weight of 51.7 kDa. By SDS-PAGE, the apparent molecular weight of rh B7-1/Fc is approximately 80-90 kDa due to the glycosylation.
AA Sequence Met 1-Asn 242
Bioactivity Measured by its ability to bind human CD28 in a functional ELISA.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method
Formulation Recombinant B7-1 Protein was lyophilized from sterile PBS, pH 7.41
Host Species Homo sapiens (Human)
Description The extracellular domain (Met 1-Asn 242) of human B7-1 (NP_005182.1) precursor was fused with the C-terminal His-tagged Fc region of human IgG1 at the C-terminus
Product Background The B-lymphocyte activation antigen B7-1 (referred to as B7), also known as CD8, is a member of cell surface immunoglobulin superfamily and is expressed on the surface of antigen-presenting cells including activated B cells, macrophages and dendritic cells. As costimulatory ligands, B7-1 which exists predominantly as dimer and the related protein B7-2, interact with the costimulatory receptors CD28 and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) expressed on T cells, and thus constitute one of the dominant pathways that regulate T cell activation and tolerance, cytokine production, and the generation of CTL. The B7/CD28/CTLA4 pathway has the ability to both positively and negatively regulate immune responses. CD8 is thus regarded as promising therapeutic targets for autoimmune diseases and various carcinomas.Immune CheckpointImmune Checkpoint Detection: AntibodiesImmune Checkpoint Detection: ELISA AntibodiesImmune Checkpoint Detection: IHC AntibodiesImmune Checkpoint Detection: FCM AntibodiesImmune Checkpoint Detection: WB AntibodiesImmune Checkpoint ProteinsImmune Checkpoint TargetsCo-inhibitory Immune Checkpoint Targets ImmunotherapyCancer ImmunotherapyTargeted Therapy
Product Memo B7 Protein, Human;B7-1 Protein, Human;B7.1 Protein, Human;BB1 Protein, Human;CD28LG Protein, Human;CD28LG1 Protein, Human;LAB7 Protein, Human
Product Type Recombinant Protein
Purity Greater than 95% as determined by SDS-PAGE
Source HEK293 Cells
Storage Store recombinant protein under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Terminal Val 35
Usage Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use