Recombinant Amelotin Protein, Human (Fc Tag) Recombinant Proteins The human AMTN (NP_997722.1) (Met1-Gln209) was expressed with the Fc region of mouse IgG1 at the C-terminus The recombinant human AMTN/mFc comprises 427a.a and has a predicted molecular weight of 46.2 kDa. The apparent molecular weight of the monomer is approximately 54 kDa in SDS-PAGE under reducing conditions.
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Formulation: The recombinant human AMTN/mFc comprises 427a.a and has a predicted molecular weight of 46.2 kDa. The apparent molecular weight of the monomer is approximately 54 kDa in SDS-PAGE under reducing conditions.
Source: HEK293 Cells
Usage: Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use

Recombinant Amelotin Protein, Human (Fc Tag)

Formulation: Recombinant Amelotin Protein was lyophilized from sterile PBS, pH 7.4.1

Source: HEK293 Cells

Product Name Recombinant Amelotin Protein, Human (Fc Tag)
Product Type Recombinant Protein
Source HEK293 Cells
Formulation Recombinant Amelotin Protein was lyophilized from sterile PBS, pH 7.4.1
Molecular Weight The recombinant human AMTN/mFc comprises 427a.a and has a predicted molecular weight of 46.2 kDa. The apparent molecular weight of the monomer is approximately 54 kDa in SDS-PAGE under reducing conditions.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method
Purity Greater than 85% as determined by SDS-PAGE
Description The human AMTN (NP_997722.1) (Met1-Gln209) was expressed with the Fc region of mouse IgG1 at the C-terminus
Host Species Homo sapiens (Human)
Usage Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use
Storage Store recombinant protein under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
AA Sequence Met1-Gln209
Product Background Amelotin (AMTN) is a tooth enamel protein which is expressed in maturation-stage ameloblasts and also in the internal basal lamina of junctional epithelium, a unique epithelial structure attached to the tooth surface which protects against the constant microbiological challenge to the periodontium. TNF-α stimulates AMTN gene transcription in human gingival epithelial cells via C/EBP1, C/EBP2, and YY1 elements in the human AMTN gene promoter.AMTN mRNA levels increased at 6 h and reached maximum at 24 h in GE1 cells. Luciferase activities of the mouse AMTN gene promoter constructs were induced by TGFβ1. AMTN mRNA levels were induced at the initiation of apoptosis by TGFβ1, which mediated through the Smad3 bindings to SBEs in the mouse AMTN gene promoter. Amelotin (Amtn) is a recently identified enamel protein secreted by ameloblasts at late stage of enamel development. Runt‑related transcription factor 2 (Runx2) in combination with the coactivator core‑binding factor β (Cbfβ) regulates the early stages of tooth development.
Memo UNQ689 Protein, Human
Terminal Leu 17
Bioactivity Please contact us for detailed information