Recombinant ALDH3A1 Protein, Human (His Tag) Recombinant Proteins The human ALDH3A1 (AAH04370.1) (Met 1-His 453) was fused with a polyhistidine tag at the N-terminus The recombinant human ALDH3A1 consists of 472a.a and has a calculated molecular weight of 52.6 kDa. It migrates as an approximately 50 kDa band in SDS-PAGE under reducing conditions.
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Formulation: The recombinant human ALDH3A1 consists of 472a.a and has a calculated molecular weight of 52.6 kDa. It migrates as an approximately 50 kDa band in SDS-PAGE under reducing conditions.
Source: Baculovirus-Insect Cells
Usage: Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use

Recombinant ALDH3A1 Protein, Human (His Tag)

Formulation: Recombinant ALDH3A1 Protein was lyophilized from sterile 20mM Tris, 500mM NaCl, pH 7.4, 10% gly1

Source: Baculovirus-Insect Cells

Product Name Recombinant ALDH3A1 Protein, Human (His Tag)
Product Type Recombinant Protein
Source Baculovirus-Insect Cells
Formulation Recombinant ALDH3A1 Protein was lyophilized from sterile 20mM Tris, 500mM NaCl, pH 7.4, 10% gly1
Molecular Weight The recombinant human ALDH3A1 consists of 472a.a and has a calculated molecular weight of 52.6 kDa. It migrates as an approximately 50 kDa band in SDS-PAGE under reducing conditions.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method
Purity Greater than 90% as determined by SDS-PAGE
Description The human ALDH3A1 (AAH04370.1) (Met 1-His 453) was fused with a polyhistidine tag at the N-terminus
Host Species Homo sapiens (Human)
Usage Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use
Storage Store recombinant protein under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
AA Sequence Met 1-His 453
Product Background Aldehyde dehydrogenase 3A1 (ALDH3A1) is a metabolic enzyme that catalyzes the oxidation of various aldehydes. Certain types of epithelial tissues in mammals, especially those continually exposed to environmental stress (e.g., corneal epithelium), express ALDH3A1 at high levels and its abundance in such tissues is perceived to help to maintain cellular homeostasis under conditions of oxidative stress. Metabolic as well as non-metabolic roles for ALDH3A1 have been associated with its mediated resistance to cellular oxidative stress. Aldehyde dehydrogenase 1A1 (ALDH1A1) and ALDH3A1 are corneal crystallins. They protect inner ocular tissues from ultraviolet radiation (UVR)-induced oxidative damage through catalytic and non-catalytic mechanisms. Additionally, ALDH3A1 has been postulated to play a regulatory role in the corneal epithelium based on several studies that report an inverse association between ALDH3A1 expression and corneal cell proliferation. Aldehyde dehydrogenase 3A1 (ALDH3A1) plays an important role in many cellular oxidative processes, including cancer chemoresistance, by metabolizing activated forms of oxazaphosphorine drugs such as cyclophosphamide (CP) and its analogues, such as mafosfamide (MF), ifosfamide (IFM), and 4-hydroperoxycyclophosphamide (4-HPCP). Compounds that can selectively target ALDH3A1 could permit delineation of its roles in these processes and could restore chemosensitivity in cancer cells that express this isoenzyme. ALDH3A1 may act to protect corneal cells against cellular oxidative damage by metabolizing toxic lipid peroxidation products (e.g., 4-HNE), maintaining cellular GSH levels and redox balance, and operating as an antioxidant.
Memo ALDH3 Protein, Human;ALDHIII Protein, Human
Terminal Met
Bioactivity Please contact us for detailed information