Recombinant ALK-1 Protein, Canine (Fc Tag) Recombinant Proteins The canine ACVRL1(E2R174) (Met1-Gln119) was expressed with the Fc region of human IgG1 at the C-terminus The recombinant canine ACVRL1/Fc is a disulfide-linked homodimer. The reduced monomer comprises 339a.a and has a predicted molecular weight of 37.9 kDa. The apparent molecular weight of the protein is approximately 43-47 kDa in SDS-PAGE under reducing conditions.
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Formulation: The recombinant canine ACVRL1/Fc is a disulfide-linked homodimer. The reduced monomer comprises 339a.a and has a predicted molecular weight of 37.9 kDa. The apparent molecular weight of the protein is approximately 43-47 kDa in SDS-PAGE under reducing conditions.
Source: HEK293 Cells
Usage: Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use

Recombinant ALK-1 Protein, Canine (Fc Tag)

Formulation: Recombinant ALK-1 Protein was lyophilized from sterile PBS, pH 7.4.1

Source: HEK293 Cells

Product Name Recombinant ALK-1 Protein, Canine (Fc Tag)
Product Type Recombinant Protein
Source HEK293 Cells
Formulation Recombinant ALK-1 Protein was lyophilized from sterile PBS, pH 7.4.1
Molecular Weight The recombinant canine ACVRL1/Fc is a disulfide-linked homodimer. The reduced monomer comprises 339a.a and has a predicted molecular weight of 37.9 kDa. The apparent molecular weight of the protein is approximately 43-47 kDa in SDS-PAGE under reducing conditions.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method
Purity Greater than 95% as determined by SDS-PAGE
Description The canine ACVRL1(E2R174) (Met1-Gln119) was expressed with the Fc region of human IgG1 at the C-terminus
Host Species Canine
Usage Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use
Storage Store recombinant protein under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
AA Sequence Met1-Gln119
Product Background Activin A receptor, type II-like 1 (ACVRL1), also known as ALK-1 (activin receptor-like kinase 1), is an endothelial-specific type I receptor of the TGF-beta (transforming growth factor beta) receptor family of ligands. On ligand binding, a heteromeric receptor complex forms consisting of two type II and two type I transmembrane serine/threonine kinases. ACVRL1 protein is expressed in certain blood vessels of kidney, spleen, heart and intestine, serving as an important role during vascular development. Mutations in ACVRL1 gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2 and vascular disease.
Uniprot Number E2R174
Terminal Gly 22
Bioactivity Measured by its ability to inhibit BMP9-induced alkaline phosphatase production by MC3T3-E1 cells.The ED50 for this effect is typically 5-15 ng/mL in the presence of 2 ng/mL of recombinant human BMP-9.