Recombinant ALK-1 Protein, Mouse (His & Fc Tag) Recombinant Proteins The mouse ALK1 (NP_033742.2) precursor (Met 1-Pro 119) was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus The secreted recombinant mouse ALK1/Fc is a disulfide-linked homodimer after removal of the signal peptide. The reduced monomer comprises 345a.a with a predicted molecular weight of 39 kDa. As a result of glycosylation, it migrates as an approximately 50-55 kDa band in SDS-PAGE under reducing condit
$ $99 In stock
Formulation: The secreted recombinant mouse ALK1/Fc is a disulfide-linked homodimer after removal of the signal peptide. The reduced monomer comprises 345a.a with a predicted molecular weight of 39 kDa. As a result of glycosylation, it migrates as an approximately 50-55 kDa band in SDS-PAGE under reducing condit
Source: HEK293 Cells
Usage: Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use

Recombinant ALK-1 Protein, Mouse (His & Fc Tag)

Formulation: Recombinant ALK-1 Protein was lyophilized from sterile PBS, pH 7.41

Source: HEK293 Cells

Product Name Recombinant ALK-1 Protein, Mouse (His & Fc Tag)
Product Type Recombinant Protein
Source HEK293 Cells
Formulation Recombinant ALK-1 Protein was lyophilized from sterile PBS, pH 7.41
Molecular Weight The secreted recombinant mouse ALK1/Fc is a disulfide-linked homodimer after removal of the signal peptide. The reduced monomer comprises 345a.a with a predicted molecular weight of 39 kDa. As a result of glycosylation, it migrates as an approximately 50-55 kDa band in SDS-PAGE under reducing condit
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method
Purity Greater than 95% as determined by SDS-PAGE
Description The mouse ALK1 (NP_033742.2) precursor (Met 1-Pro 119) was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus
Host Species Mouse
Usage Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use
Storage Store recombinant protein under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
AA Sequence Met 1-Pro 119
Product Background Activin A receptor, type II-like 1 (ACVRL1), also known as ALK-1 (activin receptor-like kinase 1), is an endothelial-specific type I receptor of the TGF-beta (transforming growth factor beta) receptor family of ligands. On ligand binding, a heteromeric receptor complex forms consisting of two type II and two type I transmembrane serine/threonine kinases. ACVRL1 protein is expressed in certain blood vessels of kidney, spleen, heart and intestine, serving as an important role during vascular development. Mutations in ACVRL1 gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2 and vascular disease.
Memo Acvrlk1 Protein, Mouse;AI115505 Protein, Mouse;AI427544 Protein, Mouse;Alk1 Protein, Mouse
Terminal Asp 23
Bioactivity Measured by its ability to inhibit BMP9-induced alkaline phosphatase production by MC3T3E1 mouse chondrogenic cells. David, L. et al. (2007) Blood 109 1953.The ED50 for this effect is typically 60-300 ng/mL in the presence of 2 ng/mL of recombiant human BMP9.