Recombinant ALK4/ACVR1B Protein, Human (His Tag) Recombinant Proteins The human ACVR1B (NP_004293.1) extracellular domain (Met 1-Glu 126) was expressed, with a C-terminal polyhistidine tag The recombinant human ACVR1B consists of 114a.a and has a predicted molecular weight of 13 kDa. In SDS-PAGE under reducing conditions, the apparent molecular weight of rh ACVR1B is approximately 18-20 kDa due to glycosylation.
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Formulation: The recombinant human ACVR1B consists of 114a.a and has a predicted molecular weight of 13 kDa. In SDS-PAGE under reducing conditions, the apparent molecular weight of rh ACVR1B is approximately 18-20 kDa due to glycosylation.
Source: HEK293 Cells
Usage: Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use

Recombinant ALK4/ACVR1B Protein, Human (His Tag)

Formulation: Recombinant ALK4/ACVR1B Protein was lyophilized from sterile PBS, pH 7.41

Source: HEK293 Cells

Product Name Recombinant ALK4/ACVR1B Protein, Human (His Tag)
Product Type Recombinant Protein
Source HEK293 Cells
Formulation Recombinant ALK4/ACVR1B Protein was lyophilized from sterile PBS, pH 7.41
Molecular Weight The recombinant human ACVR1B consists of 114a.a and has a predicted molecular weight of 13 kDa. In SDS-PAGE under reducing conditions, the apparent molecular weight of rh ACVR1B is approximately 18-20 kDa due to glycosylation.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method
Purity Greater than 92% as determined by SDS-PAGE
Description The human ACVR1B (NP_004293.1) extracellular domain (Met 1-Glu 126) was expressed, with a C-terminal polyhistidine tag
Host Species Homo sapiens (Human)
Usage Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use
Storage Store recombinant protein under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
AA Sequence Met 1-Glu 126
Product Background ALK-4 (Activin Receptor-Like Kinase 4) or ACVR1B (Activin A Receptor, type 1B), belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family, and TGFB receptor subfamily. ALK-4/ACVR1B acts as a transducer of activin or activin like ligands signals. Activin binds to either ACVR2A or ACVR2B and then forms a complex with ACVR1B. The known type II activin receptors include ActRII and ActRIIB, while the main type I activin receptor in mammalian cells is ALK-4 (ActRIB). In the presence of activin, type II and type I receptors form complexes whereby the type II receptors activate ALK-4 through phosphorylation. The activated ALK-4, in turn, transduces signals downstream by phosphorylation of its effectors, such as Smads, to regulate gene expression and affect cellular phenotype. ALK-4/ACVR1B is an important regulator of vertebrate development, with roles in mesoderm induction, primitive streak formation, gastrulation, dorsoanterior patterning, and left-right axis determination.
Memo ACTRIB Protein, Human;ACVRLK4 Protein, Human;ALK4 Protein, Human;SKR2 Protein, Human
Terminal Ser 24
Bioactivity Measured by its binding ability in a functional ELISA. Immobilized human TDGF1 at 2 ug/ml (100 ul/well) can bind human ALK-4 with a linear range of 0.032-4 ug/ml.