Recombinant AKT3 Protein, Human (GST Tag) Recombinant Proteins The full length of human PKBG (NP_005456.1) (Met 1-Glu 479) was expressed with the GST tag at the N-terminus The recombinant human PKBG/GST chimera consists of 704a.a and predicts a molecular weight of 81 kDa which is also estimated by SDS-PAGE.
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Formulation: The recombinant human PKBG/GST chimera consists of 704a.a and predicts a molecular weight of 81 kDa which is also estimated by SDS-PAGE.
Source: Baculovirus-Insect Cells
Usage: Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use

Recombinant AKT3 Protein, Human (GST Tag)

The product is for non-human research only. Not for therapeutic or veterinary use.

Catalog No: bt-204779

Molecular Weight: The recombinant human PKBG/GST chimera consists of 704a.a and predicts a molecular weight of 81 kDa which is also estimated by SDS-PAGE.

Formulation: Recombinant AKT3 Protein was lyophilized from sterile PBS, pH 7.41

Source: Baculovirus-Insect Cells

Product Name Recombinant AKT3 Protein, Human (GST Tag)
AA Sequence Met 1-Glu 479
Bioactivity No Kinase Activity
Description The full length of human PKBG (NP_005456.1) (Met 1-Glu 479) was expressed with the GST tag at the N-terminus
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method
Formulation Recombinant AKT3 Protein was lyophilized from sterile PBS, pH 7.41
Host Species Homo sapiens (Human)
Molecular Weight The recombinant human PKBG/GST chimera consists of 704a.a and predicts a molecular weight of 81 kDa which is also estimated by SDS-PAGE.
Product Background v-akt murine thymoma viral oncogene homolog 3 (AKT3), also known as PKB-GAMMA, with AKT1/PKBalpha, AKT2/PKBbeta, are the memerbers of Akt kinase family, share extensive structural similarity and perform common as well as unique functions within cells. The Akt signaling cascade initiates at the cell surface when growth factors or other extracellular stimuli activate phosphoinositide 3-kinase (PI3K). AKT3 was discovered to be the predominant isoform activated in sporadic melanomas. Levels of activity increased during melanoma progression with metastatic melanomas having the highest activity. Although mechanisms of AKT3 activation remain to be fully characterized, overexpression of AKT3 and decreased PTEN activity play important roles in this process. Targeted reduction of AKT3 activity decreased survival of melanoma tumor cells leading to inhibition of tumor development, which may be therapeutically effective for shrinking tumors in melanoma patients. AKT2 and AKT3 play an important role in the viability of human malignant glioma cells. Targeting AKT2 and AKT3 may hold promise for the treatment of patients with gliomas.
Product Memo MPPH Protein, Human;MPPH2 Protein, Human;PKB-GAMMA Protein, Human;PKBG Protein, Human;PRKBG Protein, Human;RAC-gamma Protein, Human;RAC-PK-gamma Protein, Human;STK-2 Protein, Human
Product Type Recombinant Protein
Purity Greater than 90% as determined by SDS-PAGE
Source Baculovirus-Insect Cells
Storage Store recombinant protein under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Terminal Met
Usage Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use