Recombinant Human PCSK9 (D374Y) Protein Recombinant Proteins Recombinant Human PCSK9 (D374Y) Protein PCSK9(Gln 31 - Gln 692 (D374Y))AAI166619.1Poly-hisHuman PCSK9 (D374Y) Protein is fused with a polyhistidine tag at the C-terminus, and has a calculated MW of 72 kDa. The predicted N-terminus is Gln 31. The reducing (R) protein migrates as 18 kDa and 65 kDa in
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Formulation: Recombinant Human PCSK9 (D374Y) Protein PCSK9(Gln 31 - Gln 692 (D374Y))AAI166619.1Poly-hisHuman PCSK9 (D374Y) Protein is fused with a polyhistidine tag at the C-terminus, and has a calculated MW of 72 kDa. The predicted N-terminus is Gln 31. The reducing (R) protein migrates as 18 kDa and 65 kDa in
Source: HEK293
Usage: Our recombinant proteins are For Research Use Only. This product is not intended or approved for human, diagnostics or veterinary use

Recombinant Human PCSK9 (D374Y) Protein

The product is for non-human research only. Not for therapeutic or veterinary use.

Catalog No: bt-205205

Molecular Weight: Recombinant Human PCSK9 (D374Y) Protein PCSK9(Gln 31 - Gln 692 (D374Y))AAI166619.1Poly-hisHuman PCSK9 (D374Y) Protein is fused with a polyhistidine tag at the C-terminus, and has a calculated MW of 72 kDa. The predicted N-terminus is Gln 31. The reducing (R) protein migrates as 18 kDa and 65 kDa in

Formulation: Recombinant human PCSK9 (D374Y) protein was lyophilized from 0.22 μm filtered solution in PBS, pH7.4.

Source: HEK293

Product Name Recombinant Human PCSK9 (D374Y) Protein
Bioactivity Active. Please contact us for the detailed information.
Endotoxin Less than 1.0 EU per μg of recombinant human PCSK9 (D374Y) protein by the LAL method
Formulation Recombinant human PCSK9 (D374Y) protein was lyophilized from 0.22 μm filtered solution in PBS, pH7.4.
Host Species Homo sapiens (Human)
Molecular Weight Recombinant Human PCSK9 (D374Y) Protein PCSK9(Gln 31 - Gln 692 (D374Y))AAI166619.1Poly-hisHuman PCSK9 (D374Y) Protein is fused with a polyhistidine tag at the C-terminus, and has a calculated MW of 72 kDa. The predicted N-terminus is Gln 31. The reducing (R) protein migrates as 18 kDa and 65 kDa in
Product Background Proprotein convertase subtilisin/kexin type 9 (PCSK9), is an enzyme which in humans is encoded by the PCSK9 gene. This gene encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. This protein plays a major regulatory role in cholesterol homeostasis. PCSK9 binds to the epidermal growth factor-like repeat A (EGF-A) domain of the low-density lipoprotein receptor (LDLR), inducing LDLR degradation. PCSK9 may also have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a rare form of autosomal dominant familial hypercholesterolemia (HCHOLA3).Especially,the D374Y mutation results in higher affinity of PCSK9 for LDLR.
Product Type Recombinant Protein
Purity > 92% as determined by SDS-PAGE.
Source HEK293
Stability Recombinant human PCSK9 (D374Y) protein was stable up to 12 months from date of receipt at -70℃
Storage Store recombinant human PCSK9 (D374Y) protein under sterile conditions at -20℃ to -80℃. It is recommended that the recombinant protein be aliquoted for optimal storage.
Synonym PCSK9, FH3, HCHOLA3, LDLCQ1, NARC1, PC9
Terminal Gln 31
Uniprot No Q8NBP7
Usage Our recombinant proteins are For Research Use Only. This product is not intended or approved for human, diagnostics or veterinary use