Recombinant Human ErbB4 / Her4 Protein
The product is for non-human research only. Not for therapeutic or veterinary use.
Catalog No: bt-205465
Molecular Weight: Recombinant Human ErbB4 / Her4 Protein has a calculated MW of 70.6 kDa. The recombinant protein migrates as 95-110 kDa on a SDS-PAGE gel under reducing (R) condition due to glycosylation.
Formulation: Recombinant human ErbB4 / Her4 protein was lyophilized from 0.22 μm filtered solution in PBS, pH7.4.
|Product Name||Recombinant Human ErbB4 / Her4 Protein|
|Endotoxin||Less than 1.0 EU per μg of recombinant human ErbB4 / Her4 protein by the LAL method.|
|Formulation||Recombinant human ErbB4 / Her4 protein was lyophilized from 0.22 μm filtered solution in PBS, pH7.4.|
|Host Species||Homo sapiens (Human)|
|Molecular Weight||Recombinant Human ErbB4 / Her4 Protein has a calculated MW of 70.6 kDa. The recombinant protein migrates as 95-110 kDa on a SDS-PAGE gel under reducing (R) condition due to glycosylation.|
|Product Background||Receptor tyrosine-protein kinase erbB-4 (ErbB4), also known as Her4, is a single-pass type I transmembrane glycoprotein that is a member of the ErbB family of tyrosine kinase receptors. ErbB family members serve as receptors for the epidermal growth factor (EGF) family of growth factors. ErbB4 is expressed in normal skeletal muscle, heart, pituitary, brain and several breast carcinomas. ERBB4 contains multiple furin-like cysteine rich domains, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins-2 and -3, heparin-binding EGF-like growth factor and betacellulin. Ligand binding induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. ErbB4 appears to play important roles in neuronal development, development of the heart and cancer. ERBB4 has been shown to interact with: DLG4, NRG1, STAT5A, and YAP1. Mutations in this gene have been associated with cancer. Other single-nucleotide polymorphisms and a risk haplotype have been linked to schizophrenia.|
|Product Type||Recombinant Protein|
|Purity||> 95% as determined by SDS-PAGE.|
|Stability||Recombinant human ErbB4 / Her4 protein was stable up to 12 months from date of receipt at -70℃|
|Storage||Store recombinant human ErbB4 / Her4 protein under sterile conditions at -20℃ to -80℃. It is recommended that the recombinant protein be aliquoted for optimal storage.|
|Synonym||HER4, ErbB4, MGC138404, p180erbB4|
|Usage||Our recombinant proteins are For Research Use Only. This product is not intended or approved for human, diagnostics or veterinary use|