Recombinant Human G-CSFR / CD114 Protein Recombinant Proteins Recombinant Human G-CSFR / CD114 Protein has a calculated MW of 69 kDa. The recombinant protein migrates as 94 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
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Formulation: Recombinant Human G-CSFR / CD114 Protein has a calculated MW of 69 kDa. The recombinant protein migrates as 94 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Source: HEK293
Usage: Our recombinant proteins are For Research Use Only. This product is not intended or approved for human, diagnostics or veterinary use

Recombinant Human G-CSFR / CD114 Protein

The product is for non-human research only. Not for therapeutic or veterinary use.

Catalog No: bt-205476

Molecular Weight: Recombinant Human G-CSFR / CD114 Protein has a calculated MW of 69 kDa. The recombinant protein migrates as 94 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Formulation: Recombinant human G-CSFR / CD114 protein was lyophilized from 0.22 μm filtered solution in PBS, pH7.4.

Source: HEK293

Product Name Recombinant Human G-CSFR / CD114 Protein
Endotoxin Less than 1.0 EU per μg of recombinant human G-CSFR / CD114 protein by the LAL method.
Formulation Recombinant human G-CSFR / CD114 protein was lyophilized from 0.22 μm filtered solution in PBS, pH7.4.
Host Species Homo sapiens (Human)
Molecular Weight Recombinant Human G-CSFR / CD114 Protein has a calculated MW of 69 kDa. The recombinant protein migrates as 94 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Product Background Granulocyte Colony Stimulating Factor Receptor (G-CSFR) is also known as Cluster of Differentiation 114 (CD114), CSF3R and GCSF, is a cell-surface receptor for the granulocyte colony-stimulating factor (G-CSF), a cytokine that plays a critical role in the regulation of the activation, proliferation, differentiation, and survival of the neutrophilic granulocyte lineage. G-CSFR belongs to a family of cytokine receptors known as the hematopoietin receptor family. This type I  membrane protein has a composite structure consisting of an immunoglobulin(Ig)-like domain, a cytokine receptor-homologous (CRH) domain and three fibronectin type I II (FNIII) domains in the extracellular region. G-CSFR is present mainly on precursor cells in the bone marrow, and, in response to stimulation by G-CSF, initiates cell proliferation and differentiation into mature neutrophilic granulocytes and macrophages. G-CSFR mediates the specific effect of GCSF through activating a variety of intracellular signaling cascades, including the Jak/Stat, PI3/Akt, Ras-Raf-MAP kinase, and Src family kinase pathways, and thus functions in defense against infection, inflammation and repair, and in the maintenance of steady state hematopoiesis. Mutations in this gene are a cause of Kostmann syndrome, also known as severe congenital neutropenia. Mutations in the intracellular part of this receptor are also associated with certain types of leukemia.
Product Type Recombinant Protein
Purity > 95% as determined by SDS-PAGE.
Source HEK293
Stability Recombinant human G-CSFR / CD114 protein was stable up to 12 months from date of receipt at -70℃
Storage Store recombinant human G-CSFR / CD114 protein under sterile conditions at -20℃ to -80℃. It is recommended that the recombinant protein be aliquoted for optimal storage.
Synonym CSF3R, CD114, GCSFR
Terminal Glu 25
Uniprot No Q99062
Usage Our recombinant proteins are For Research Use Only. This product is not intended or approved for human, diagnostics or veterinary use