Recombinant Human G-CSFR / CD114 Protein
The product is for non-human research only. Not for therapeutic or veterinary use.
Catalog No: bt-205476
Molecular Weight: Recombinant Human G-CSFR / CD114 Protein has a calculated MW of 69 kDa. The recombinant protein migrates as 94 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Formulation: Recombinant human G-CSFR / CD114 protein was lyophilized from 0.22 μm filtered solution in PBS, pH7.4.
|Product Name||Recombinant Human G-CSFR / CD114 Protein|
|Endotoxin||Less than 1.0 EU per μg of recombinant human G-CSFR / CD114 protein by the LAL method.|
|Formulation||Recombinant human G-CSFR / CD114 protein was lyophilized from 0.22 μm filtered solution in PBS, pH7.4.|
|Host Species||Homo sapiens (Human)|
|Molecular Weight||Recombinant Human G-CSFR / CD114 Protein has a calculated MW of 69 kDa. The recombinant protein migrates as 94 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.|
|Product Background||Granulocyte Colony Stimulating Factor Receptor (G-CSFR) is also known as Cluster of Differentiation 114 (CD114), CSF3R and GCSF, is a cell-surface receptor for the granulocyte colony-stimulating factor (G-CSF), a cytokine that plays a critical role in the regulation of the activation, proliferation, differentiation, and survival of the neutrophilic granulocyte lineage. G-CSFR belongs to a family of cytokine receptors known as the hematopoietin receptor family. This type I membrane protein has a composite structure consisting of an immunoglobulin(Ig)-like domain, a cytokine receptor-homologous (CRH) domain and three fibronectin type I II (FNIII) domains in the extracellular region. G-CSFR is present mainly on precursor cells in the bone marrow, and, in response to stimulation by G-CSF, initiates cell proliferation and differentiation into mature neutrophilic granulocytes and macrophages. G-CSFR mediates the specific effect of GCSF through activating a variety of intracellular signaling cascades, including the Jak/Stat, PI3/Akt, Ras-Raf-MAP kinase, and Src family kinase pathways, and thus functions in defense against infection, inflammation and repair, and in the maintenance of steady state hematopoiesis. Mutations in this gene are a cause of Kostmann syndrome, also known as severe congenital neutropenia. Mutations in the intracellular part of this receptor are also associated with certain types of leukemia.|
|Product Type||Recombinant Protein|
|Purity||> 95% as determined by SDS-PAGE.|
|Stability||Recombinant human G-CSFR / CD114 protein was stable up to 12 months from date of receipt at -70℃|
|Storage||Store recombinant human G-CSFR / CD114 protein under sterile conditions at -20℃ to -80℃. It is recommended that the recombinant protein be aliquoted for optimal storage.|
|Synonym||CSF3R, CD114, GCSFR|
|Usage||Our recombinant proteins are For Research Use Only. This product is not intended or approved for human, diagnostics or veterinary use|