Recombinant Mouse TIM-3 / HAVCR2 Protein
The product is for non-human research only. Not for therapeutic or veterinary use.
Catalog No: bt-205608
Molecular Weight: Recombinant mouse TIM-3 / HAVCR2 protein has a calculated molecular mass of 21 kDa. The recombinant protein migrates as 33-47 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Formulation: Recombinant mouse TIM-3 / HAVCR2 protein was lyophilized from 0.22 μm filtered solution in PBS, pH7.4.
|Product Name||Recombinant Mouse TIM-3 / HAVCR2 Protein|
|Endotoxin||Less than1.0 EU per μg of recombinant mouse TIM-3 / HAVCR2 protein by the LAL method.|
|Formulation||Recombinant mouse TIM-3 / HAVCR2 protein was lyophilized from 0.22 μm filtered solution in PBS, pH7.4.|
|Molecular Weight||Recombinant mouse TIM-3 / HAVCR2 protein has a calculated molecular mass of 21 kDa. The recombinant protein migrates as 33-47 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.|
|Product Background||Hepatitis A virus cellular receptor 2 is also known as HAVCR2, FLJ14428, KIM3, TIM3, TIMD3, is a member of the TIM family of immune regulating molecules with one Ig-like V-type domain and a Ser/Thr-rich mucin stalk. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells and their associated cytokines are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. The 2 types of cells also cross-regulate the functions of the other. HAVCR2 is a Th1-specific cell surface protein that regulates macrophage activation and enhances the severity of experimental autoimmune encephalomyelitis in mice. HAVCR2 regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell homing. Dysregulation of the HAVCR2-galectin-9 pathway could underlie chronic autoimmune disease states in human, such as multiple sclerosis.|
|Product Type||Recombinant Protein|
|Purity||> 95% as determined by SDS-PAGE.|
|Stability||Recombinant mouse TIM-3 / HAVCR2 protein was stable up to 12 months from date of receipt at -70℃|
|Storage||Store recombinant mouse TIM-3 / HAVCR2 protein under sterile conditions at -20℃ to -80℃. It is recommended that the recombinant protein be aliquoted for optimal storage.|
|Synonym||HAVCR2, TIM3, TIMD3, FLJ14428, KIM3|
|Usage||Our recombinant proteins are For Research Use Only. This product is not intended or approved for human, diagnostics or veterinary use|