Recombinant Mouse Defb2 Protein
Recombinant Proteins
Formulation:
Source:
E.coli
Usage:
Our recombinant proteins are For Research Use Only. This product is not intended or approved for human, diagnostics or veterinary use
Recombinant Mouse Defb2 Protein
The product is for non-human research only. Not for therapeutic or veterinary use.
Catalog No: bt-206106
Formulation: The Mouse BD-2 was lyophilized from a 0.2µm filtered concentrated solution in PBS, pH7.4.
Source: E.coli
| Product Name | Recombinant Mouse Defb2 Protein |
|---|---|
| AA Sequence | AVGSLKSIGY EAELDHCHTN GGYCVRAICP PSARRPGSCF PEKNPCCKYM K. |
| Bioactivity | Determined by the ability to chemoattract immature human dendritic cells at a concentration of 10-100ng/ml. |
| Formulation | The Mouse BD-2 was lyophilized from a 0.2µm filtered concentrated solution in PBS, pH7.4. |
| Host Species | Mouse |
| Product Background | The Defensin family are highly similar in their protein sequence and are microbicidal & cytotoxic peptides made by neutrophils. Beta Defensin-1 is an antimicrobial peptide having the resistance of epithelial surfaces to microbial colonization. Beta Defensin-1 has close proximity to Defensin Alpha-1 and has been implicated in the pathogenesis of cystic fibrosis. Skin of patients having atopic dermatitis patients and mycosis fungoides (non-lesional and lesional) show lower human Beta Defensin-1 mRNA expression and higher human Beta Defensin-2 and human Beta Defensin-3 mRNA expression. BBeta Defensin is highly expressed by epithelial cells. Beta-defensin 1 may play a role in the pathogenesis of severe sepsis. Variation in human Beta Defensin-1 contributes to asthma diagnosis, with apparent gender-specific effects. Human Beta Defensin-3 is a dimer, while Human BD-1 and Human BD-2 are monomeric. The expression of Human BD1 is correlated with induction profiles in gingival keratinocytes. The level of expression of human DEFB1 mRNA is lower than that of human BD3 and human BD-2 in reconstructed epidermis. Human BD1 is down-regulated in human prostatic and renal carcinomas. |
| Product Memo | BD 2 Mouse Beta Defensin-2 Mouse Recombinant |
| Product Type | Recombinant Protein |
| Purity | > 98% as determined by (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE |
| Reconstitution | It is recommended to reconstitute the lyophilized Beta Defensin-2 in sterile 18M-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions |
| Source | E.coli |
| Stability | Recombinant protein is stable up to 1 year at -80℃ |
| Storage | Lyophilized Beta Defensin-2 Recombinant although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution BD-2 should be stored at 4°C between 2-7 days and for future use below -18°C. Please prevent freeze-thaw cycles. |
| Synonym | Beta-defensin 2, BD-2, mBD-2, Defensin beta 2, Defb2, MGC129140, MGC129141 |
| Uniprot No | P82020 |
| Usage | Our recombinant proteins are For Research Use Only. This product is not intended or approved for human, diagnostics or veterinary use |