Recombinant Human HECW2 Protein, GST Tag Recombinant Proteins Human HECW2 partial ORF ( NP_065811, 637 a.a. - 745 a.a.) recombinant protein with GST-tag at N-terminal
$ $99 In stock
Formulation:
Source: Wheat Germ
Usage: Our recombinant proteins are For Research Use Only. This product is not intended or approved for human, diagnostics or veterinary use

Recombinant Human HECW2 Protein, GST Tag

The product is for non-human research only. Not for therapeutic or veterinary use.

Catalog No: bt-212315

Source: Wheat Germ

Product Name Recombinant Human HECW2 Protein, GST Tag
Host Species Homo sapiens (human)
Description Human HECW2 partial ORF ( NP_065811, 637 a.a. - 745 a.a.) recombinant protein with GST-tag at N-terminal
Product Background This gene encodes a member of a family of E3 ubiquitin ligases which plays an important role in the proliferation, migration and differentiation of neural crest cells as a regulator of glial cell line-derived neurotrophic factor (GDNF)/Ret signaling. This gene also plays an important role in angiogenesis through stabilization of endothelial cell-to-cell junctions as a regulator of angiomotin-like 1 stability. The encoded protein contains an N-terminal calcium/lipid-binding (C2) domain involved in membrane targeting, two-four WW domains responsible for cellular localization and substrate recognition, and a C-terminal homologous with E6-associated protein C-terminus (HECT) catalytic domain. Naturally occurring mutations in this gene are associated with neurodevelopmental delay, hypotonia, and epilepsy. The decreased expression of this gene in the aganglionic colon is associated with Hirschsprung's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]
Product Type Recombinant Protein
Source Wheat Germ
Storage Store at -8 centigrade. Aliquot to avoid repeated freezing and thawing.
Synonym HECW2, HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2, E3 ubiquitin-protein ligase HECW2, KIAA1301, NEDL2, NEDD4-related E3 ubiquitin ligase NEDL2, NEDD4-like E3 ubiquitin-protein ligase 2, HECT, C2 and WW domain-containing protein 2, DKFZp686M17164
Uniprot No Q9P2P5
Usage Our recombinant proteins are For Research Use Only. This product is not intended or approved for human, diagnostics or veterinary use