Recombinant Human HDAC1 Protein, His Tag Recombinant Proteins Recombinant Human HDAC1 fussed with His tag was expressed in insect cells
$ $99 In stock
Formulation:
Source: Insect cells
Usage: Our recombinant proteins are For Research Use Only. This product is not intended or approved for human, diagnostics or veterinary use

Recombinant Human HDAC1 Protein, His Tag

The product is for non-human research only. Not for therapeutic or veterinary use.

Catalog No: bt-212442

Formulation: Liquid. In 50mM TRIS, pH 8.0, 138mM sodium chloride and 10% glycerol

Source: Insect cells

Product Name Recombinant Human HDAC1 Protein, His Tag
Formulation Liquid. In 50mM TRIS, pH 8.0, 138mM sodium chloride and 10% glycerol
Host Species Homo sapiens (human)
Description Recombinant Human HDAC1 fussed with His tag was expressed in insect cells
Product Background Human HDAC1 (HD1) was the first protein to be linked to histone deacetylase activity. It is homologous to the yeast protein Rpd31, a relationship which has since come to define the “class I HDACs”. HDAC1 promotes transcriptional repression by deacetylating lysine ε-amino groups in histone N-terminal tails, a function frequently carried out in association with multi-protein transcription repression complexes such as NuRD3, Sin34 and CoREST6. Ubiquitously expressed in human tissues HDAC1-containing complexes appear to contribute the greater part of (at least class I) deacetylase activity in HeLa nuclear extracts. Aside from its interaction with co-repressors, HDAC1 activity may be regulated by post-translation modifications such as phosphorylation9 and sumoylation or binding to the inhibitor maspin, a tumor-suppressive serpin homolog. Although originally described as a “histone deacetylase”, HDAC1 has been shown to catalyze the regulatory deacetylation of non-histone proteins, including p53. Overexpression of HDAC1 has been found in various cancer types. HDAC inhibitors (HDACi) have shown considerable promise as anti-cancer agents and HDACi compounds from multiple chemical classes are in stages of drug development ranging from preclinical to phase III trials.
Product Type Recombinant Protein
Source Insect cells
Storage Long Term Storage -80°C
Synonym HD1, RPD3, GON-10, RPD3L1, histone deacetylase 1, reduced potassium dependency, yeast homolog-like
Uniprot No Q13547
Usage Our recombinant proteins are For Research Use Only. This product is not intended or approved for human, diagnostics or veterinary use