Recombinant IkB alpha Protein, Human (His Tag) Recombinant Proteins The human NFKBIA (NP_065390.1) (Phe 2-Leu 317) was expressed, with a polyhistide tag at the N-terminus The recombinant human NFKBIA consisting of 323a.a and has a calculated molecular weight of 36.4 kDa. It migrates as an approximately 38 kDa band in SDS-PAGE under reducing conditions.
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Formulation: The recombinant human NFKBIA consisting of 323a.a and has a calculated molecular weight of 36.4 kDa. It migrates as an approximately 38 kDa band in SDS-PAGE under reducing conditions.
Source: E. coli
Usage: Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use

Recombinant IkB alpha Protein, Human (His Tag)

The product is for non-human research only. Not for therapeutic or veterinary use.

Catalog No: bt-212559

Molecular Weight: The recombinant human NFKBIA consisting of 323a.a and has a calculated molecular weight of 36.4 kDa. It migrates as an approximately 38 kDa band in SDS-PAGE under reducing conditions.

Formulation: Recombinant IkB alpha Protein was lyophilized from sterile 50mM Tris, 0.5M NaCl, pH 8.01

Source: E. coli

Product Name Recombinant IkB alpha Protein, Human (His Tag)
Molecular Weight The recombinant human NFKBIA consisting of 323a.a and has a calculated molecular weight of 36.4 kDa. It migrates as an approximately 38 kDa band in SDS-PAGE under reducing conditions.
AA Sequence Phe 2-Leu 317
Bioactivity Please contact us for detailed information
Formulation Recombinant IkB alpha Protein was lyophilized from sterile 50mM Tris, 0.5M NaCl, pH 8.01
Host Species Homo sapiens (Human)
Description The human NFKBIA (NP_065390.1) (Phe 2-Leu 317) was expressed, with a polyhistide tag at the N-terminus
Product Background Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (IkB alpha, NFKBIA, or IKBA), is a member of the NF-kappa-B inhibitor family that function to inhibit the NF-kB transcription factor. NFKBIA inhibits NF-kB by masking the nuclear localization signals (NLS) of NF-kB proteins and keeping them sequestered in an inactive state in the cytoplasm. In addition, NFKBIA blocks the ability of NF-κB transcription factors to bind to DNA, which is required for NF-kB's proper functioning. Signal-induced degradation of I kappa B alpha exposes the nuclear localization signal of NF-kappa B, thus allowing it to translocate into the nucleus and activate transcription from responsive genes. An autoregulatory loop is established when NF-kappa B induces expression of the I kappa B alpha gene and newly synthesized I kappa B alpha accumulates in the nucleus where it negatively regulates NF-kappa B-dependent transcription. As part of this post-induction repression, the nuclear export signal on I kappa B alpha mediates transport of NF-kappa B-I kappa B alpha complexes from the nucleus to the cytoplasm. Deletion of NFKBIA has an effect that is similar to the effect of EGFR amplification in the pathogenesis of glioblastoma and is associated with comparatively short survival. Polymorphisms in NFKBIA may be important in pre-disposition to and outcome after treatment, of multiple myeloma (MM). The NFKBIA gene product, IkappaBalpha, binds to NF-kappaB preventing its activation and is important in mediating resistance to apoptosis in B-cell lymphoproliferative diseases.
Product Memo IKBA Protein, Human;MAD-3 Protein, Human;NFKBI Protein, Human
Product Type Recombinant Protein
Purity Greater than 90% as determined by SDS-PAGE
Source E. coli
Storage Store recombinant protein under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Terminal Met
Usage Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use
Last Modified Mar 08 2019