Recombinant Lipocalin-2 Protein, Rat (His Tag) Recombinant Proteins The rat LCN2 (P30152) (Met 1-Asn 198) was fused with a polyhistidine tag at the C-terminus The recombinant rat LCN2 comprises 188a.a with and has a predicted molecular weight of 21.9 kDa. It migrates as an approximately 25 kDa band in reduced SDS-PAGE.
$ $99 In stock
Formulation: The recombinant rat LCN2 comprises 188a.a with and has a predicted molecular weight of 21.9 kDa. It migrates as an approximately 25 kDa band in reduced SDS-PAGE.
Source: Baculovirus-Insect Cells
Usage: Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use

Recombinant Lipocalin-2 Protein, Rat (His Tag)

The product is for non-human research only. Not for therapeutic or veterinary use.

Catalog No: bt-213157

Molecular Weight: The recombinant rat LCN2 comprises 188a.a with and has a predicted molecular weight of 21.9 kDa. It migrates as an approximately 25 kDa band in reduced SDS-PAGE.

Formulation: Recombinant Lipocalin-2 Protein was lyophilized from sterile 20mM Tris, 500mM NaCl, 10% glycerol, pH 7.01

Source: Baculovirus-Insect Cells

Product Name Recombinant Lipocalin-2 Protein, Rat (His Tag)
AA Sequence Met 1-Asn 198
Bioactivity Measured by its ability to bind Iron(III) dihydroxybenzoic acid [Fe(DHBA)3]. The binding of Fe(DHBA)3 results in the quenching of Trp fluorescence in Lipocalin2. It binds >1.0 uM of Fe(DHBA)3.
Description The rat LCN2 (P30152) (Met 1-Asn 198) was fused with a polyhistidine tag at the C-terminus
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method
Formulation Recombinant Lipocalin-2 Protein was lyophilized from sterile 20mM Tris, 500mM NaCl, 10% glycerol, pH 7.01
Host Species Rat
Molecular Weight The recombinant rat LCN2 comprises 188a.a with and has a predicted molecular weight of 21.9 kDa. It migrates as an approximately 25 kDa band in reduced SDS-PAGE.
Product Background Lipocalin-2 (LCN2), also known as neutrophil gelatinase-associated lipocalin (NGAL), is a 25 kDa protein belonging to the lipocalin superfamily. It was initially found in activated neutrophils, however, many other cells, like kidney tubular cells, may produce NGAL in response to various insults. This protein is released from injured tubular cells after various damaging stimuli, is already known by nephrologists as one of the most promising biomarkers of incoming Acute Kidney Injury (AKI). Recent evidence also suggests its role as a biomarker in a variety of other renal and non-renal conditions. Moreover, recent studies seem to suggest a potential involvement of this factor also in the genesis and progression of chronic kidney diseases. NGAL is the first known mammalian protein which specifically binds organic molecules called siderophores, which are high-affinity iron chelators. NGAL, first known as an antibacterial factor of natural immunity, and an acute phase protein, is currently one of the most interesting and enigmatic proteins involved in the process of tumor development. acting as an intracellular iron carrier and protecting MMP9 from proteolytic degradation, NGAL has a clear pro-tumoral effect, as has already been observed in different tumors (e.g. breast, stomach, oesophagus, brain) in humans. In thyroid carcinomas, NGAL is strongly induced by NF-kB, an important factor involved both in tumor growth and in the link between chronic inflammation and neoplastic development. Thus, Lipocalin-2 (LCN2/NGAL) has been implicated in a variety of processes including cell differentiation, proliferation, survival and morphogenesis.
Product Type Recombinant Protein
Purity Greater than 90% as determined by SDS-PAGE
Source Baculovirus-Insect Cells
Storage Store recombinant protein under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Terminal Gln 21
Uniprot No P30152
Usage Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use