Recombinant Human proBDNF Protein Recombinant Proteins
$ $99 In stock
Formulation:
Source: E.coli
Usage: Our recombinant proteins are For Research Use Only. This product is not intended or approved for human, diagnostics or veterinary use

Recombinant Human proBDNF Protein

The product is for non-human research only. Not for therapeutic or veterinary use.

Catalog No: bt-222338

Formulation: proBDNF was lyophilized from a concentrated (0.5mg/ml) solution in 20mM PB, pH 8.0 and 500mM NaCl.

Source: E.coli

Product Name Recombinant Human proBDNF Protein
AA Sequence The sequence of the first five N-terminalaa was determined and was found to be Met-Ala-Pro-Met-Lys.
Formulation proBDNF was lyophilized from a concentrated (0.5mg/ml) solution in 20mM PB, pH 8.0 and 500mM NaCl.
Host Species Homo sapiens (Human)
Product Background proBDNF (the precursor form of Brain-derived neurotrophic factor) interacts preferentially with p75NTR (the pan-neurotrophin receptor p75) and vps10p domain-containing receptor sortilin and induces neuronal apoptosis, while the mature BDNF selectively binds with great affinity to the TrkB kinase receptor and promotes the survival, growth and differentiation of neurons. Since proneurotrophins and mature neurotrophins bring forth opposite biological effects, proBDNF cleavage in the neuronal system is regulated in a specific and cell-context dependent manner. proBDNF has an important role in negative regulation of neurotrophic actions in the brain.
Product Memo proBDNF Human Precursor Brain-Derived Neurotrophic Factor Human Recombinant
Product Type Recombinant Protein
Purity >95% as determined by RP-HPLC and SDS-PAGE.
Reconstitution It is recommended to reconstitute the lyophilized proBDNF in sterile 18M-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions
Source E.coli
Stability Recombinant protein is stable up to 1 year at -80℃
Storage Lyophilized proBDNF although stable at room temperature for up to 3 weeks, should be stored under sterile conditions at -20°C. Upon reconstitution proBDNF should be stored at 4°C between 2-7 days and for future use below -20°C. Please avoid repeated freeze-thaw cycles.
Synonym proBDNF, Precursor Form Brain-derived Neurotrophic Factor
Uniprot No P23560
Usage Our recombinant proteins are For Research Use Only. This product is not intended or approved for human, diagnostics or veterinary use
Last Modified Mar 08 2019