pros Antibody
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Product Specs
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
Made-to-order (14-16 weeks)
Synonyms
CG17228 antibody; Homeobox protein prospero antibody; Pro antibody; PROS 1 antibody; PROS 2 antibody; proS antibody; PROS_DROME antibody; PROS1 antibody; PROS2 antibody; Prosp antibody; Voila antibody
Target Names
pros
Uniprot No.
Target Background
Function
Prospero is a homeodomain protein that plays a crucial role in regulating neuronal identity. As a transcription factor, it controls the expression of genes like *ftz*, *eve*, and *en* in specific neuroblast progeny, and modulates the transcriptional activity of other homeodomain proteins, such as Dfd. Its function is indispensable for proper neuronal differentiation, axonal outgrowth, and pathfinding in both the central and peripheral nervous systems. Moreover, Prospero collaborates with the protein Brat to ensure proper asymmetric stem cell self-renewal.
Gene References Into Functions
- Research has shown that the loss of Prospero hinders the suppression of SCA8-associated neurodegeneration by Spoonbill. This suggests a potential genetic interaction and functional collaboration between Prospero and Spoonbill. PMID: 28722203
- Prospero is essential for the differentiation of astrocytes, but not for ensheathing glia, despite their shared lineage. PMID: 26893340
- The RanGEF Bj1 promotes nuclear export of Prospero, facilitating neuroblast self-renewal. PMID: 25312250
- Transient nuclear localization of Prospero induces quiescence in neural progenitors. PMID: 25354199
- Studies have shown that Prospero indirectly restricts the formation of CO(2) neurons through miR-279 and directly by repressing the shared target molecules Nerfin-1 and Esg. PMID: 22049409
- The homeo-prospero domain plays a crucial role in regulating Prospero's nuclear localization and DNA binding specificity. PMID: 12429095
- The subcellular localization of Prospero is dynamic. Its carboxy terminus, including the homeodomain and Prospero domain, plays a significant role in regulating these changes. PMID: 12529405
- Complete nervous system development necessitates a full complement of Prospero, and gradual decreases in its levels can proportionally alter nervous system development and function. PMID: 12605454
- The combined expression of Prospero, Seven-up, and Elav identifies progenitor cell types during sense organ differentiation in the Drosophila antenna. PMID: 12606283
- Prospero is a transcription factor that controls the differentiation between color photoreceptor cell fates. PMID: 12791270
- Research has identified an intron region critical for Prospero twintron splicing, providing insights into the molecular mechanism of splicing regulation involving competition between different spliceosomes. PMID: 14966268
- The neural precursor gene *prospero* is essential for *nerfin-1* expression in the developing Drosophila central nervous system. PMID: 15617679
- DTRAF1 binds to Baz and acts downstream of Egr in the Mira/Pros telophase rescue pathway. PMID: 17139248
- The spatio-temporal expression of Prospero is precisely regulated to ensure the correct development and function of the nervous system in *Drosophila melanogaster*. PMID: 17223099
- Altered Prospero expression influences the age of onset of male mating behavior. PMID: 17436071
- In the compound eye, *prospero* is transcribed specifically in R7 photoreceptors and cone cells. PMID: 18635611
- Prospero is a transcription factor that is transported to the nucleus during Drosophila embryonic nervous system development. PMID: 11262236
Database Links
Protein Families
Prospero homeodomain family
Subcellular Location
Nucleus. Cytoplasm, cell cortex. Cytoplasm.
Q&A
Antibody research plays a critical role in virology, immunology, and therapeutic development. Below are structured FAQs addressing key methodological and analytical challenges in academic research, informed by current studies and technical guidelines.
Advanced Research Questions
How are engineered pro-antibodies used to mitigate on-target toxicity in monoclonal therapies?
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Innovative design:
| Parameter | Masked Antibody | Activated Antibody |
|---|---|---|
| Binding affinity (KD) | >100 nM | 2-5 nM |
| Toxicity in vivo | Reduced liver uptake | Target-specific action |
What strategies resolve contradictions between neutralizing antibody titers and clinical protection?
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Integrated approaches:
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Case study: COVID-19 convalescent plasma trials prioritized IgG titers >1:320 for therapeutic efficacy, yet some patients with lower titers still showed clinical improvement .
How do researchers optimize custom antibody production for rare epitope targets?
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Technical workflow:
Methodological Best Practices
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Cohort stratification: In serosurveys, oversample high-risk subgroups (e.g., healthcare workers) to improve statistical power .
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Antibody stability testing: Store recombinant antibodies at -80°C with 5% glycerol to prevent aggregation .
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Data transparency: Publish raw optical density (OD) values and threshold calculations to enable cross-study comparisons .
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