Further research indicates PROS-1's crucial role in development. Studies using C. elegans have demonstrated that pros-1 deletion results in larval lethality, a phenotype rescued by both pros-1 and human Prox1 transgenes. Moreover, RNAi-mediated knockdown of pros-1 impacted sensory neuron function, affecting morphology, sensory behavior, and cold tolerance. These findings collectively highlight PROS-1's function as a transcriptional regulator in glial cells. (PMID: 27402188)