PRPF6 Antibody
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Product Specs
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Lead Time
Typically, we can ship products within 1-3 business days of receiving your order. Delivery time may vary depending on the purchase method or location. For specific delivery times, please consult your local distributor.
Synonyms
Androgen receptor N terminal domain transactivating protein 1 antibody; ANT 1 antibody; ANT1 antibody; C20orf14 antibody; hPrp6 antibody; p102 U5 small nuclear ribonucleoprotein particle binding protein antibody; pre-mRNA processing factor 6 antibody; Pre-mRNA-processing factor 6 antibody; PRP6 homolog antibody; PRP6 pre mRNA processing factor 6 homolog antibody; PRP6_HUMAN antibody; PRPF6 antibody; Putative mitochondrial outer membrane protein import receptor antibody; TOM antibody; U5 snRNP-associated 102 kDa protein antibody; U5-102 kDa protein antibody; U5-102K antibody
Target Names
PRPF6
Uniprot No.
Target Background
Function
PRPF6 is involved in pre-mRNA splicing as a component of the U4/U6-U5 tri-snRNP complex, a crucial building block of the spliceosome. It enhances dihydrotestosterone-induced transactivation of the androgen receptor (AR) and dexamethasone-induced transactivation of the glucocorticoid receptor (NR3C1). However, it does not affect estrogen-induced transactivation.
Gene References Into Functions
- PRPF6 plays a significant role in cancer by influencing the splicing of specific growth-related genes. PMID: 24788092
- Our research identifies PRPF6 as the sixth gene implicated in pre-mRNA splicing and dominant retinitis pigmentosa. This finding reinforces the hypothesis that spliceosome deficiencies contribute significantly to the molecular pathology of this disease. PMID: 21549338
- Studies demonstrate that PRP6 and PRP31 are directly phosphorylated by human PRP4 kinase (PRP4K) during their incorporation into B complexes. PMID: 20118938
- PRPF6 has been identified as a coactivator for the androgen receptor. PMID: 12039962
- The interaction of CD2BP2 with a tri-snRNP bridging protein (Prp6), along with CD2BP2's absence from the tri-snRNP, suggests a possible role in tri-snRNP assembly. PMID: 15840814
- C20orf14 may be involved in lymphoma progression. PMID: 18278469
Database Links
Involvement In Disease
Retinitis pigmentosa 60 (RP60)
Subcellular Location
Nucleus, nucleoplasm. Nucleus speckle.
Tissue Specificity
Widely expressed.
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