PRSS2 Antibody

1. A study evaluated the association of claudin2 and PRSS1-PRSS2 polymorphisms with idiopathic recurrent acute (RAP) and chronic pancreatitis. PMID: 26110235
2. A PRSS2 single nucleotide polymorphism was associated with the development of alcoholic pancreatitis. PMID: 25253127
3. Serum trypsinogen-2 levels are associated with pancreatic cancer and pancreatitis. PMID: 25916077
4. Trypsin-2 overexpression enhanced tongue carcinoma cell invasion through various genetic and proteolytic mechanisms. PMID: 22909050
5. Elevated urine trypsinogen 2 levels are an independent risk factor for pancreatic fistula after pancreaticoduodenectomy. PMID: 22357509
6. A study reported a simple, rapid, easy, and noninvasive urinary trypsinogen-2 test that can diagnose or rule out most cases of acute pancreatitis. PMID: 22481290
7. Data suggests that the urinary trypsinogen-2 dipstick test is a useful tool for the early diagnosis of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis. PMID: 21946810
8. Results indicate that trypsinogen-2 is a more sensitive marker than amylase, and it can be helpful in the early diagnosis of post-ERCP pancreatitis. PMID: 21792081
9. A genetic variant of PRSS2 may contribute to the low prevalence of pancreatitis in primary hyperparathyroidism patients. PMID: 20625975
10. Hyperexpression of the PRSS2 gene is associated with pancreatic cancer. PMID: 20428826
11. A study found a borderline statistically significant association between pancreatic cancer and HAT/HCT but no association between pancreatic cancer and HAT, HCT. PMID: 20484960
12. The urine trypsinogen-2 test may be a valuable diagnostic tool in excluding the diagnosis of acute pancreatitis; it has a negative predictive value. PMID: 20517765
13. Results do not support the urinary trypsinogen-2 dipstick test (UTDT) as a replacement for standard plasma amylase in the diagnosis of acute pancreatitis (AP), however, the test demonstrated sufficient sensitivity to be used for rapid early screening of AP in clinical settings. PMID: 19752771
14. Findings indicate that up-regulation of anionic trypsinogen in pancreatic diseases does not impact physiological trypsinogen activation, but significantly limits trypsin generation under potential pathological conditions. PMID: 12709065
15. High levels of pulmonary trypsin-2 may be associated with the development of bronchopulmonary dysplasia in preterm infants. PMID: 12949286
16. The G191R variant of PRSS2 reduces intrapancreatic trypsin activity and thus protects against chronic pancreatitis. PMID: 16699518
17. Research suggests that serum trypsinogen-2 is a highly useful marker for diagnosing patients with cholangiocarcinoma, and it is superior to serum CA19-9 and CEA. PMID: 17640760
18. Co-localization of trypsin-2 and MMP-9 resulted in intracellular proMMP-9 processing, which represented fully or partially activated MMP-9. PMID: 18062964
19. A loss of function polymorphism (G191R) of anionic trypsinogen (PRSS2) provides protection against chronic pancreatitis. PMID: 18362849
20. A fusion with PRSS1 is associated with hereditary pancreatitis. PMID: 18461367
21. The primary role of trypsinogen sulfation in humans is to stimulate autoactivation of PRSS1. PMID: 18986305
22. The p.G191R variant protected against alcoholic and idiopathic chronic pancreatitis as well as alcoholic acute pancreatitis in Japan. PMID: 19052022
23. G191R PRSS2 is a rare allele in the Indian population, and data suggest a nonsignificant trend towards a protective effect from tropical calcific pancreatitis in Indians. PMID: 19077465

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HGNC: 9483

OMIM: 601564

KEGG: hsa:5645

UniGene: Hs.449281